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Kumar, Anjan
- Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory Activity in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 3 (2015), Pagination: 138-144Abstract
The present study was designed to evaluate the analgesic and anti-inflammatory activity of "Trichilia connaroides" bark using different animal models. Analgesic activity was evaluated by using various two animal models namely, Writing Test using acetic acid in mice and Hot Plate Method. The degree of analgesic activity was determined by the number of wriths was recorded for each animal in Writing Test using acetic acid in mice model and the delay in reaction time for of each animal when place in hot plate maintained at 55±0.10c is recorded in Hot Plate Method. Anti-inflammatory activity was evaluated using Formalin induced paw edema model, Croton oil ear edema in rats. Trichilia connaroides bark ethanolic extracts produced significant analgesic activity in both Hot plate and acetic acid induced writhing models in mice. In hot plate method percentage increase in reaction time was determined where as in acetic acid induced writhing model percentage decrease in writhings was determined. Evaluation of anti inflammatory activity was done by Formalin induced paw edema model, Croton oil ear edema model. In Formalin induced paw edema model mean change in paw volume and percentage protection were calculated. In croton oil ear edema model the difference between untreated ear and treated ear were determined which indicated degree of inflammatory edema. The study revealed that the "Trichilia connaroides" bark possess a significant analgesic and anti-inflammatory activity.Keywords
"Trichilia connaroides" Bark, Writing Test Using Acetic Acid, Hot Plate Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema in Rats.
- Studies on Anti-Depressant and Anti-Inflammatory Activities of Curcuma aromatica Rhizome in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 2 (2016), Pagination: 79-86Abstract
The present study was designed to evaluate the antidepressant and anti-inflammatory activity of "Curcuma aromatica" oil and "Curcuma aromatica" extract using different animal models. Antidepressant activity was evaluated by using various animal models. The degree of antidepressant activity was determined by measuring the immobility time in forced swim test and tail suspension tests. Anti-inflammatory activity was evaluated using Carrageenan induced paw edema model. Animals treated with all three doses of CAO (250,500 and 750mg/kg) witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with Imipramine (15mg/kg), as expected showed a significant decrease in the immobility time.
Carrageenan induced paw edema model was employed to evaluate the anti-inflammatory activity of ethanolic extract of "Curcuma aromatica". Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema .The study revealed that the "Curcuma aromatica" rhizome oil possess a significant antidepressant and anti-inflammatory activity.