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Virani, Paras
- Analytical Methods for Irbesartan in Bulk Drug by Ultraviolet Spectroscopy
Abstract Views :330 |
PDF Views:3
Authors
Affiliations
1 Shree Dhanvantary Pharmacy College, Kim. Surat, IN
2 Globela Pharma Private Limited. Surat, IN
1 Shree Dhanvantary Pharmacy College, Kim. Surat, IN
2 Globela Pharma Private Limited. Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 147-150Abstract
A simple, rapid and precise ultraviolet spectroscopy method was developed and validated for quantitative analysis of irbesartan in bulk drug. It is an angiotensin II receptor (AT1 subtype) antagonist. It is used for the treatment of hypertension. It shows maximum absorbance at 246 nm. Beer Lambert's was obeyed in the concentration range of in the range of 5-30 μg/ml. The method was successfully validated in accordance to USP pharmacopeia and ICH guideline for accuracy, precision, rang and linearity. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor is greater than 0.999 for irbesartan. The % Recovery/Accuracy was within the range between 98% and 102%. The percentage RSD for precision was found to be less than 2%. Thus method was successfully applied for routine analysis of irbesartan in bulk samples.Keywords
Accuracy, ICH Guideline, Irbesartan, Precision, Validation, Ultraviolet Spectroscopy USP Pharmacopeia.- Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix
Abstract Views :220 |
PDF Views:3
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 151-160Abstract
Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.Keywords
Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.- Simultaneous Estimation of Irbesartan and Atorvastatin by Q Absorption Ratio Method in Their Synthetic Mixture
Abstract Views :218 |
PDF Views:0
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN