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Kamala, Govinda Rao
- Method Development and Validation for Simultaneous Estimation of Omeprazole and Domperidone by RP-HPLC
Abstract Views :329 |
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Authors
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1 Aditya Pharmacy College, ADB Road, Surampalem, Kakinada, East Godavari District, IN
1 Aditya Pharmacy College, ADB Road, Surampalem, Kakinada, East Godavari District, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 4 (2015), Pagination: 195-205Abstract
The developed RP- HPLC method allows rapid and precise determinations of Omeprazole and domperidone, the scope of the present work is to expand and optimization of the chromatographic conditions, to develop RPHPLC method. A series of mobile phases were tried, among the various mobile phases as methanol and 0.1% ammonium acetate an ideal mobile phase, since it gave a good resolution and peak shapes with perfect optimization. The flow rate was optimized at 1 ml/min. The Linearity and Correlation Coefficient of Omeprazole and Domperidone were found to be 10-50 ug/ml, and 10.10-50.50 ug/ml 0.9996, and 0.998 respectively. The limit of detection for Omeprazole and domperidone was found to be 1.76 and 2.0 and the limit of quantification was found to be 1.87 and 1.48. The method was known to be accurate with the assay method. The % assay was found to be 97 and 98.12. The developed method was showed to a good accuracy and precision. The % RSD is for Omeprazole and Domperidone is 041 and 1.41. The Isocratic elution technique developed for the determination of Omeprazole and domperidone ideally suited for rapid and routine analysis. This method shows that good reproducibility of the results. Furthermore this method was simple, sensitive, and accurate. Degradation studies were done, here the drug stability results were in the range of acceptance criteria 85-115%.Keywords
Omeprazole, Domperidone, Optimization, Method Validation, RP-HPLC.- Development and Validation of RP-HPLC Method for Simultaneous Estimation of Paracetamol and Flupirtine Maleate
Abstract Views :302 |
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Authors
Affiliations
1 Aditya Institute of Pharmaceutical Scienecs and Research, Surampalem, Kakinada, East Godawary, Andhra Pradesh – 533 437, IN
1 Aditya Institute of Pharmaceutical Scienecs and Research, Surampalem, Kakinada, East Godawary, Andhra Pradesh – 533 437, IN