Asian Journal of Pharmaceutical Analysis

R. Madhavi ¹, A. Mohana Krishna ¹, G. Shobha Rani ¹, D. Mounika ¹

Affiliations
1 Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Rangampet, Tirupati-517501, Chittoor Dist, Andhra Pradesh, IN

Abstract

Isoniazid is an anti -tubercular drug, which is mostly used in the treatment and prevention of tuberculosis. It acts by inhibiting the synthesis of mycolic acid, required for mycobacterial cell wall synthesis in mycobacterium(M) tuberculosis. This article examines published analytical techniques that are reported so far for the determination of isoniazid in bulk, pharmaceutical formulation and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high performance liquid chromatography, high performance thin layer chromatography, capillary gas chromatography and liquid chromatography-mass spectrophotometry.

Keywords

Isoniazid, Analytical Methods, Tuberculosis, Mycolic Acid.

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G. Shobha Rani ¹, M. Lohita ¹, P. Jaya Preethi ¹, R. Madhavi ¹, B. Sunisitha ¹, D. Mounika ¹

Affiliations
1 Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, IN

Abstract

Glimepiride is an oral anti-diabetic drug, which is mostly used in the treatment of Type 2 diabetes mellitus. It acts by stimulating insulin secretions from the beta cells of pancreas and is also known to enhance the peripheral insulin sensitivity thereby decreasing insulin resistance. This article examines published analytical methods that are reported so far for the determination of glimepiride in pharmaceutical formulations and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high-performance liquid chromatography, micellarelectro kinetic capillary chromatography(MECC) with diode-array detection (DAD), liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS), liquid chromatography-mass spectroscopy (LC-MS) and thin layer chromatography (TLC).

Keywords

Glimepiride, Analytical Methods, Type 2 Diabetes Mellitus.

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