Asian Journal of Pharmaceutical Analysis

Duggi Adilakshmi ¹, Abdul Saleem Mohammad ², Nuha Rasheed ³, Kathula Umadevi ², Chandana Pasupuleti ¹

Affiliations
1 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN

Abstract

The present investigation an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing sustained release matrix tablets of Allopurinol. Sustained release matrix tablets of Allopurinol, were developed by using different drug: polymer ratio. Kollidon SR, Hydroxypropyl methylcellulose K15M, K100M as matrix former. All lubricated formulations were compressed by direct compression and by wet granulation method. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution, and swelling index. All the formulation showed compliance with pharmacopoeial standards. Among the different formulation, B8 showed sustained release of drug for 12 hours with 86.55% release. The regression coefficient value of Higuchi plot was found to be 0.9925 that showed that drug was released by diffusion mechanism. The slope value of korsmeyer ‐peppas equation was found to be 0.5062 which indicating that drug was released by non‐fickian release mechanism. The R2 value for Hixson Crowell plot was found to be 0.9919 which indicates that drug release was limited by drug particle dissolution rate and erosion of the polymer matrix. Thus, drug in combination with Hydroxy propyl methyl cellulose K100M were found to be effective in retarding the release of Allopurinol.

Keywords

DSC Studies, FTIR Studies, HPMC, Polymers, Sustained Release.

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Chandana Pasupuleti ¹, Abdul Saleem Mohammad ², Nuha Rasheed ³, Kathula Umadevi ², Duggi Adilakshmi ¹

Affiliations
1 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN

Abstract

The aim for the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increasing local action in gastric region against Helicobacter pylori. Therefore the present investigation is concerned with the development of rice bran oil entrapped zinc pectinate beads containing ofloxacin, which after oral administration were designed to prolong the gastric residence time, thus to increase the bioavailability of the drug. A suitable method of analysis of drug by UV spectrophotometry was developed. Ofloxacin showed maximum absorption at a wavelength 294.5 nm in pH 1.2 hydrochloric acid buffer. The value of regression coefficient (r²) was found to be 0.999, which showed linear relationship between concentration and absorbance. Preformulation study for drug and polymer compatibility by DSC and FTIR gave confirmation about the purity of the drug and showed no interaction between drug and the polymers.

Keywords

Ofloxacin, Buffer, DSC, FTIR, Bioavailability, Microbeads.

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