Asian Journal of Pharmaceutical Analysis

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Spectrophotometric Estimation of Dextromethorphan in Bulk Drug using Hydrotropic Solubilization Technique


Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
     

   Subscribe/Renew Journal


A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10-120μg/ml with coefficient of correlation 0.9993.The % RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.

Keywords

Dextromethorphan, Hydrotropic Study, Enhancement of Solubility, Method Development and Validation
Subscription Login to verify subscription
User
Notifications
Font Size


  • Li P Zhao L, Developing early formulations: Practice and perspective. International Journal of Pharmaceutics 341(1-2); 2007:1-19.

  • C. Neuberg, Biochem Z., 1916, 76: 107.

  • Cui Y Parallel stacking of caffeine with riboflavin in aqueous solutions: The potential mechanism for hydrotropic solubilization of riboflavin. International Journal of Pharmaceutics 15 397(1-2); 2010:36-43.

  • Jain N Jain R Jain A Pandey SP Jain DK Spectrophotometric quantitative estimation of amlodipine besylate in bulk drug and their dosage forms by using hydrotropic agent. Eurasian J. Anal. Chem. 5; 2010: 212-217.

  • Pandey S Maheshwari RK A novel Spectroscopic Method for the estimation of Ketoprofen in tablet dosage form using hydrotropic solubilization phenomenon. World Applied Sciences Journal 11; 2010:1524 - 1527.

  • Maheshwari RK Indurkhya A Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of hydrotropic solid dispersion of aceclofenac. Asian Journal of Pharmaceutics 4; 2010: 235 - 238.

  • Vemula VR Lagishetty V Lingala S Solubility enhancement techniques. Int. J. Pharm. Sci., Review and Research 5 (1); 2010: 41-51.

  • Saravanakumar G Choi KY Yoon HY Kim K Park JH Kwon IC Park K Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel. International Journal of Pharmaceutics 394; 2010: 154-161.

  • Baghel US Dhiman V. Exploring the Application of Hydrotropic Solubilization Phenomenon for Estimating Diacerein in Capsule Dosage Form by Spectrophotometry Methods. Asian Pacific Journal of Tropical Biomedicine. 2010: S1720-S1727.

  • Maheshwari RK, Lakkadwala S, Vyas R, Ghode P. Spectrophotometric determination of naproxen tablets using niacinamide as hydrotropic solubilizing additive. Journal of Current Pharmaceutical Research4; 2010: 11-14.

  • Maheshwari RK Bishnoi SR Kumar D Murali K. Digest Journal of Nanomaterials and Biostructures.5; 2010:97-100.

  • Maheswari RK Chandrawashi H, Gupta N, Quantitative estimation of aspirin in tablets and bulk sample using metformin hydrochloride as hydrotropic agent. International Journal of Pharmacy and Pharmaceutical Sciences 2010, 2, 21-23.

  • Maheshwari RK Archana A, Amit R, Megha A. Ecofriendly spectrophotometric estimation of atenolol tablets using metformin hydrochloride as hydrotropic solubilizing agent. Journal of Global Pharma Technology. 2; 2010: 93-96

  • Jayakumar C, Kumar DK, Nesakumar D, Gandhi NN. Quantitative analysis of theophylline bulk sample using sodium salicylate hydrotrope. International Journal of Pharmacy and Pharmaceutical Sciences 2; 2010:124-125.

  • Sherje AP, Anand R, Sriram W, Vanshiv SD. Mixed hydrotropy in spectrophotometric analysis of nitazoxanide. International Journal of Chem. Tech. Research 2; 2010: 1966-1969.

  • Maheshwari RK, Rajput MS, Sinha S. New quantitative estimation of benzoic acid bulk sample using calcium disodium edetate as hydrotropic solubilizing agent. Asian Journal of Pharmaceutical and Clinical Research 3; 2010: 43-45.

  • Sharma MC, Sharma S. Spectrophotometric determination of Lamivudine in Bulk and Pharmaceutical Formulation using hydrotropic Solubilization. Int. J. Pharm Tech Research3; 2011:988-991.

  • Fabregas JL, Margalet A. GLC trace analysis of Dextromethorphan and bromhexine salts in pharmaceutical preparations. Journal of Pharmaceutical Sciences. 64(6); 1975: 1005-1006

  • International Conference on Harmonization, (2005) Guidance for Industry in: Q2B Validation on Analytical Procedures. Methodology Switzerland IFPMA, 1.


Abstract Views: 915

PDF Views: 1




  • Spectrophotometric Estimation of Dextromethorphan in Bulk Drug using Hydrotropic Solubilization Technique

Abstract Views: 915  |  PDF Views: 1

Authors

Jyoti Dahiya
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Anuradha Singh
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Shiv Kumar Gupta
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Babita Kumar
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India

Abstract


A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10-120μg/ml with coefficient of correlation 0.9993.The % RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.

Keywords


Dextromethorphan, Hydrotropic Study, Enhancement of Solubility, Method Development and Validation

References