Asian Journal of Pharmaceutical Analysis

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Synthesis Of 2-(3-Substitutedamino-2, 4-Dithiobiuretoformamidino-4-Isobutoxyphenyl)-4-Methyl-5-Carboxy-1, 3-Thiazoles


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1 Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604, India
     

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A novel method has been developed for the synthesis of 2-(3-substitutedamino-2,4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.

Keywords

2-(3-Substitutedthioamidoformamidino-4-Isobutoxyphenyl)-4-Methyl-5-Carboxy-1,3-Thiazoles, Ethanol, Acetone.
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  • Synthesis Of 2-(3-Substitutedamino-2, 4-Dithiobiuretoformamidino-4-Isobutoxyphenyl)-4-Methyl-5-Carboxy-1, 3-Thiazoles

Abstract Views: 667  |  PDF Views: 0

Authors

A. S. Shendge
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604, India
D. T. Tayade
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604, India
P. R. Kale
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604, India

Abstract


A novel method has been developed for the synthesis of 2-(3-substitutedamino-2,4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.

Keywords


2-(3-Substitutedthioamidoformamidino-4-Isobutoxyphenyl)-4-Methyl-5-Carboxy-1,3-Thiazoles, Ethanol, Acetone.

References