Asian Journal of Pharmaceutical Analysis

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Spectrophotometric Estimation of Ziprasidone in Bulk and in Pharmaceutical Formulations


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1 K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
     

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A new simple, sensitive and precise visible spectrophotometric method has been developed for the determination of ziprasidone in bulk and in pharmaceutical formulations. This method is based on the hydrolysis of Ziprasidone, followed by diazotization and coupling with N-(1-naphthyl) ethylene diamine dihydrochloride to form an azo dye which was estimated at an absorption maximum of 540nm (pink color). This method has the linearity in the concentration range of 2-10 μg/ml. This method is statistically evaluated for efficacy.
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  • Spectrophotometric Estimation of Ziprasidone in Bulk and in Pharmaceutical Formulations

Abstract Views: 192  |  PDF Views: 0

Authors

N. Santhi
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
Deepthi
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
S. S. Rajendran
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
S. Gananadhamu
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
G. Devala Rao
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India
Sai Lohit
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, India

Abstract


A new simple, sensitive and precise visible spectrophotometric method has been developed for the determination of ziprasidone in bulk and in pharmaceutical formulations. This method is based on the hydrolysis of Ziprasidone, followed by diazotization and coupling with N-(1-naphthyl) ethylene diamine dihydrochloride to form an azo dye which was estimated at an absorption maximum of 540nm (pink color). This method has the linearity in the concentration range of 2-10 μg/ml. This method is statistically evaluated for efficacy.