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Glimepiride:A Review of Analytical Methods


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1 Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
     

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Glimepiride is an oral anti-diabetic drug, which is mostly used in the treatment of Type 2 diabetes mellitus. It acts by stimulating insulin secretions from the beta cells of pancreas and is also known to enhance the peripheral insulin sensitivity thereby decreasing insulin resistance. This article examines published analytical methods that are reported so far for the determination of glimepiride in pharmaceutical formulations and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high-performance liquid chromatography, micellarelectro kinetic capillary chromatography(MECC) with diode-array detection (DAD), liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS), liquid chromatography-mass spectroscopy (LC-MS) and thin layer chromatography (TLC).

Keywords

Glimepiride, Analytical Methods, Type 2 Diabetes Mellitus.
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  • Glimepiride:A Review of Analytical Methods

Abstract Views: 100  |  PDF Views: 2

Authors

G. Shobha Rani
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
M. Lohita
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
P. Jaya Preethi
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
R. Madhavi
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
B. Sunisitha
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India
D. Mounika
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, India

Abstract


Glimepiride is an oral anti-diabetic drug, which is mostly used in the treatment of Type 2 diabetes mellitus. It acts by stimulating insulin secretions from the beta cells of pancreas and is also known to enhance the peripheral insulin sensitivity thereby decreasing insulin resistance. This article examines published analytical methods that are reported so far for the determination of glimepiride in pharmaceutical formulations and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high-performance liquid chromatography, micellarelectro kinetic capillary chromatography(MECC) with diode-array detection (DAD), liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS), liquid chromatography-mass spectroscopy (LC-MS) and thin layer chromatography (TLC).

Keywords


Glimepiride, Analytical Methods, Type 2 Diabetes Mellitus.