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Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form


Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277, India
     

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The present work was aimed at method development and validation for simultaneous estimation of Telmisartan and Ramipril by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and λmax of Telmisartan and Ramipril were found to be 232nm and 222nm respectively. Concentration ranges were found to be 4-20μg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Telmisartan and Ramipril respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Telmisartan and Ramipril. LOD and LOQ ranges were found to be 0.177 and 0.539μg/mL and 0.298 and 0.903μg/mL for Telmisartan and Ramipril respectively. This method was validated using ICH guidelines.

Keywords

Telmisartan, Ramipril, UV-Spectrophotometric Method, Simultaneous Equation, Validation.
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  • Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form

Abstract Views: 88  |  PDF Views: 3

Authors

N. Vanaja
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277, India
Preethi
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277, India
S. Y. Manjunath
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277, India
Krishanu Pal
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277, India

Abstract


The present work was aimed at method development and validation for simultaneous estimation of Telmisartan and Ramipril by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and λmax of Telmisartan and Ramipril were found to be 232nm and 222nm respectively. Concentration ranges were found to be 4-20μg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Telmisartan and Ramipril respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Telmisartan and Ramipril. LOD and LOQ ranges were found to be 0.177 and 0.539μg/mL and 0.298 and 0.903μg/mL for Telmisartan and Ramipril respectively. This method was validated using ICH guidelines.

Keywords


Telmisartan, Ramipril, UV-Spectrophotometric Method, Simultaneous Equation, Validation.