Asian Journal of Pharmaceutical Analysis

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Simultaneous Formulation, Estimation and Evaluation of Ofloxacin Microbeads


Affiliations
1 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
2 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
     

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The aim for the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increasing local action in gastric region against Helicobacter pylori. Therefore the present investigation is concerned with the development of rice bran oil entrapped zinc pectinate beads containing ofloxacin, which after oral administration were designed to prolong the gastric residence time, thus to increase the bioavailability of the drug. A suitable method of analysis of drug by UV spectrophotometry was developed. Ofloxacin showed maximum absorption at a wavelength 294.5 nm in pH 1.2 hydrochloric acid buffer. The value of regression coefficient (r2) was found to be 0.999, which showed linear relationship between concentration and absorbance. Preformulation study for drug and polymer compatibility by DSC and FTIR gave confirmation about the purity of the drug and showed no interaction between drug and the polymers.

Keywords

Ofloxacin, Buffer, DSC, FTIR, Bioavailability, Microbeads.
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  • Simultaneous Formulation, Estimation and Evaluation of Ofloxacin Microbeads

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Authors

Chandana Pasupuleti
Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
Abdul Saleem Mohammad
Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
Nuha Rasheed
Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
Kathula Umadevi
Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India
Duggi Adilakshmi
Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India

Abstract


The aim for the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increasing local action in gastric region against Helicobacter pylori. Therefore the present investigation is concerned with the development of rice bran oil entrapped zinc pectinate beads containing ofloxacin, which after oral administration were designed to prolong the gastric residence time, thus to increase the bioavailability of the drug. A suitable method of analysis of drug by UV spectrophotometry was developed. Ofloxacin showed maximum absorption at a wavelength 294.5 nm in pH 1.2 hydrochloric acid buffer. The value of regression coefficient (r2) was found to be 0.999, which showed linear relationship between concentration and absorbance. Preformulation study for drug and polymer compatibility by DSC and FTIR gave confirmation about the purity of the drug and showed no interaction between drug and the polymers.

Keywords


Ofloxacin, Buffer, DSC, FTIR, Bioavailability, Microbeads.