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Lao, Thuan Duc

miRNA-141 as the Biomarker for Human Cancers

Abstract Views :281 | PDF Views:176

Authors

Thuan Duc Lao ¹, Phuong Kim Truong ², Thuy Ai Huyen Le ²

Affiliations
1 University of Science, Vietnam National University, Ho Chi Minh City, VN
2 Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 2 (2018), Pagination: 42-49

Abstract

microRNA (miRNA) is considered to be a pivotal role in human numerous biological process, and their abnormal expression that functions either as tumor suppressor or oncogenes results in human cancer initiation and development microRNA-141 (miR-141), belonged to the miR-200 family, located at 12p13.31 and is also found to be abundantly expressed in many human cancers. Additionally, Prognostic and predictive miR-141 signatures have been defined for a variety of cancer types. This review summarized the biogenesis and processing of miRNA, as well as the roles of miR-141 in human cancer pathways, its targets and the potential utility of miR-141 as prognostic biomarkers.

Keywords

Biomarker, Human Cancer, microRNA, microRNA-141.

Full Text

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The Major Molecular Causes of Familial Hypercholesterolemia

Abstract Views :257 | PDF Views:139

Authors

Phuong Kim Truong ¹, Thuan Duc Lao ¹, Thuy Huyen Ai Le ¹

Affiliations
1 Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 2 (2018), Pagination: 60-68

Abstract

Familial Hypercholesterolemia (FH) is a common dominant disorder of cholesterol metabolism characterized by elevated serum cholesterol level which results in increasing risk of many diseases. The major cause of FH is the loss-of-function in Low Density Lipoprotein Receptor (LDLR), Apolipoprotein B-100 (ApoB-100), Low Density Lipoprotein Receptor Adapter Protein (LDLRAP1), and Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) gene that revealed to the defects in the uptake and degradation of Low Density Lipoprotein (LDL) via the LDLR pathway. In this review, we have highlighted the molecular disorder in LDLR, ApoB-100, LDLRAP1 and PCSK gene, leading to the possible accession on early diagnosis, screening of FH based on the clinical characteristics, family history, evaluated LDL-Cholesterol levels and recently genetic testing aided, hence molecular based therapy will be applied or recommended to FH patients.

Keywords

Apolipoprotein B-100 (ApoB-100), Familial Hypercholesterolemia, Low Density Lipoprotein Receptor, Low Density Lipoprotein Receptor Adapter Protein, Proprotein Convertase Subtilisin/Kexin Type 9.

Full Text

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Characteristic of ZMYND10 Gene’s Promoter Hypermethylation in Nasopharyngeal Carcinoma Biopsies from Vietnamese Patients

Abstract Views :240 | PDF Views:130

Authors

Thuan Duc Lao ¹, Thuy Ai Huyen Le ²

Affiliations
1 University of Science, Vietnam National University, Ho Chi Minh City, VN
2 Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 3 (2018), Pagination: 69-74

Abstract

Silencing of tumor suppressor gene, which caused by the DNA hypermethylation, an epigenetic modification, has been reported to be involved in human various cancers, including nasopharyngeal carcinoma. The aims of this study were to identify and evaluate the hypermethylation frequency of the ZMYND10 promoter, which located at 3p21.3, in nasopharyngeal biopsies from Vietnamese patients by Nested Methylation Specific PCR (Nested MSP). In current study, ninety tumor biopsies and ninety healthy samples, which were obtained from Cho Ray hospital, were enrolled into study. As the results, the hypermethylation frequency of ZMYND10 gene promoter was more frequent in tumor biopsies. In detail, the hypermethylation frequency of ZMYND10 gene promoter were 81.11% (73 of 90 samples), and 45.56% (41 of 90 samples) for in NPC biopsies and non-cancerous specimens. A trend toward positive association was found between hypermethylation of ZMYND10 gene and nasopharyngeal carcinoma (p < 0.0007). Additionally, the high Odds ratio (OR) and Relative risk were observed (OR = 5.13, RR = 2.49) (p <0.0001). In conclusion, our data suggested that the hypermethylation of ZMYND10 gene promoter is a significant in nasopharyngeal carcinoma in Vietnamese patients.

Keywords

Hypermethylation, Nasopharyngeal Carcinoma, Tumor Suppressor Gene, ZMYND10.

Full Text

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Characteristic of ZMYND10 Gene’s Promoter Hypermethylation in Nasopharyngeal Carcinoma Biopsies from Vietnamese Patients

miRNA-141 as the Biomarker for Human Cancers

Development of Stem-Loop Real-Time PCR Technique for miRNA-141 Expression Analysis in Nasopharyngeal Carcinoma

Abstract Views :206 | PDF Views:180

Authors

Thuan Duc Lao ¹, Thuy Ai Huyen Le ¹

Affiliations
1 Faculty of Biotechnology, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ward Co Giang, District 1, HCMC, Ho Chi Minh City, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 11, No 2-4 (2019), Pagination: 30-36

Abstract

Background: The deregulation of miRNA-141 (miR-141) has been reported to be involved in development and progression of many various types of human cancers. Previously, it has been demonstrated that miR-141 served as the oncogenic role in nasopharyngeal carcinoma in different countries. However, in Vietnam, to our knowledge, there are limit study of the types of evaluation of miR-141 expression. Objective: For the aims to find out the novel diagnosis strategies and promising therapies for many human based on the expression of miRNA, we the stem-loop qRT-PCR method described here is to detect mature miRNA-141 in a fast, specific, accurate, and reliable manner. Methods: StL-miR-141, known as stem-loop RT primer is applied for Reversed transcriptase assay, followed by Real-time PCR assay using StL-F, STL-R primer and SYBR-Green. Results: Experimentally, this method was applied in detection of miR-141 in Vietnamese NPC biopsy samples, as the results, 5 of six NPC were positive to miR-141 expression. Moreover, the electrophoresis analysis was performed to evaluate the Specificity. The assay has shown high specific for miR-141 detection. Conclusion: We successfully designed the stem-loop RT primer, StL-F, STL-R primer, might be used as a rapid, simple method for the detectionwith a wider scope to apply this method onto the Vietnamese population.

Keywords

miRNAs, miR-141, Stem-Loop RT PCR.

Full Text

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The Prognosis Value of CDH-1 Methylation-The Epigenetic Biomarker in Nasopharyngeal Carcinoma:Systematic Review and Meta-Analysis

Abstract Views :188 | PDF Views:168

Authors

Thuan Duc Lao ¹, Phuong Kim Truong ¹, Hue Hong Thieu ², Thuy Ai Huyen Le ¹

Affiliations
1 Faculty of Biotechnology, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City − 700000, VN
2 Faculty of Biology and Biotechnology, Ho Chi Minh City University of Science, Hồ Chí Minh − 700000, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 11, No 2-4 (2019), Pagination: 68-74

Abstract

Background: The phenome of CDH-1 gene methylation has been reported to be associated with the nasopharyngeal tumorigenesis. Objective: Aiming to evaluate the association between the CDH-1 gene methylation and nasopharyngeal cancer, and its correlation could be used as an epigenetic biomarker for nasopharyngeal cancer risk based on meta-analysis. Materials and Methods: Relevant articles were identified by searching MEDLINE database. The frequency and Odds Ratio (OR) were applied to estimate the effect of CDH-1 methylation based on random-/fix-effects models. Results: Total of 12 studies, including 500 samples from NPC patients and 201 samples from non-cancerous samples, were enrolled in current study. Overall, the frequency of CDH-1 gene methylation were 48.50% and 3.09% in the case and control group, respectively. The association between the CDH-1 gene methylation and risk of NPC was also confirmed by calculating OR value of 15.33 (95% CI = 7.82-30.06), based on the fix-effects model. Additionally, the significant association was also found between the methylation of CDH-1 gene and subgroups. Conclusion: this meta-analysis provides scientific evidences to suggest the CDH-1 methylation was the potential biomarker for risk of NPC.

Keywords

CDH-1, Epigenetic Biomarker, Nasopharyngeal carcinoma, Meta-Analysis.

Full Text

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Epidemiology, Incidence, Mortality of Cervical Cancer in Southeast Asia and their Relationship: An Update Report

Abstract Views :253 | PDF Views:133

Authors

Nam Hoang Dang Phan ¹, Tung Thanh Nguyen ¹, Nhan Thanh Vo ¹, Trinh Tuyet Thi Le ¹, Tran Bao Hoang Tran ¹, Phuong Kim Truong ¹, Thuy Ai Huyen Le ¹, Thuan Duc Lao ¹

Affiliations
1 Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN

Source

Asian Journal of Pharmaceutical Research and Health Care, Vol 12, No 3 (2020), Pagination: 97-101

Abstract

Cervical cancer is the leading-caused cancer death in women worldwide, especially occurring in the developing countries. The understanding of the incidence, mortality, and their relationship with the Human Development Index (HDI) and its three dimensions, including gross national income per capita, education index, and life expectancy, is crucial to establish the best way to prevent the increasing of cervical cancer in future. The data of the incidence (-ASR), mortality (-ASR), HDI were extracted from the GLOBOCAN and Human Development Reports database. Person Correlation Coefficient was applied to characterize the relationship among them. The incidence and mortality of Cervical Cancer in Southeast Asia (total new cases: 62,456 cases, counting for 19, 81%; new death cases: 35,738, counting for 21.22%), ranked in the top three of Asian regions. There was the negative correlation between the incidence-ASR, mortality-ASR with HDI, and its three dimensions. A significant correlation between the mortality-ASR rate of cervical cancer and Life expectancy at birth was recorded. The cancer of cervix gravitates to Asian region, including Southeast Asian countries. There was a significant relationship between the mortality-ASR rate of cervical cancer and Life expectancy at birth.

Keywords

Cervical Cancer, Incidence, Mortality, Southeast Asia.

Full Text

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