A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Truong, Phuong Kim
- miRNA-141 as the Biomarker for Human Cancers
Authors
1 University of Science, Vietnam National University, Ho Chi Minh City, VN
2 Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 2 (2018), Pagination: 42-49Abstract
microRNA (miRNA) is considered to be a pivotal role in human numerous biological process, and their abnormal expression that functions either as tumor suppressor or oncogenes results in human cancer initiation and development microRNA-141 (miR-141), belonged to the miR-200 family, located at 12p13.31 and is also found to be abundantly expressed in many human cancers. Additionally, Prognostic and predictive miR-141 signatures have been defined for a variety of cancer types. This review summarized the biogenesis and processing of miRNA, as well as the roles of miR-141 in human cancer pathways, its targets and the potential utility of miR-141 as prognostic biomarkers.Keywords
Biomarker, Human Cancer, microRNA, microRNA-141.References
- Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell. 2005; 122(1):6–7. Crossref PMid:16009126
- Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993; 75(5):843–54. Crossref
- Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014; 15(8):509–24. Crossref PMid:25027649
- Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet. 2008; 9(2):102–14. Crossref PMid:18197166
- Liu Y, Zhao R, Wang H, Luo Y, Wang X, Niu W, et al. miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma. Cell Death Dis. 2016; 24(7):e2156. Crossref PMid:27010857 PMCid:PMC4823963
- Bushati N, Cohen SM. microRNA functions. Annu Rev Cell Dev Biol. 2007; 23:175–205. Crossref PMid:17506695
- Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6(11):857–66. Crossref PMid:17060945
- Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol. 2009; 27(34):5848–56. Crossref PMid:19884536 PMCid:PMC2793003
- Spence T, Bruce J, Yip KW, Liu FF. MicroRNAs in nasopharyngeal carcinoma. Chin Clin Oncol. 2016; 5(2):17. Crossref PMid:27121877
- Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281–97. Crossref
- Macfarlane LA, Murphy PR. MicroRNA: Biogenesis, function and role in cancer. Curr Genomics. 2010; 11(7):537–61. Crossref PMid:21532838 PMCid:PMC3048316
- Lin SL, Kim H, Ying SY. Intron-mediated RNA interference and microRNA (miRNA). Front Biosci. 2008; 13:2216–30. Crossref PMid:17981704
- Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 2004; 10(12):1957–66. Crossref PMid:15525708 PMCid:PMC1370684
- Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23(20):4051–60. Crossref PMid:15372072 PMCid:PMC524334
- Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009; 10(2):126–39. Crossref PMid:19165215
- Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003; 425(6956):415–9. Crossref PMid:14508493
- Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes and Development. 2003; 17(24):3011–6. Crossref PMid:14681208 PMCid:PMC305252
- Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat Rev Mol Cell Biol. 2010; 11(4):252–63. Crossref PMid:20216554
- Shenouda SK, Alahari SK. MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev. 2009; 28(3-4):369–78. Crossref PMid:20012925
- Zhang L, Deng T, Li X, Liu H, Zhou H, Ma J, et al. microRNA-141 is involved in a nasopharyngeal carcinomarelated genes network. Carcinogenesis. 2010; 31(4):559–66. Crossref PMid:20053927
- Liu Y, Ding Y, Huang J, Wang S, Ni W, Guan J, et al. MiR141 suppresses the migration and invasion of HCC cells by targeting Tiam1. PLoS One. 2014; 9(2):e88393. Crossref PMid:24551096 PMCid:PMC3923786
- Wu SM, Ai HW, Zhang DY, Han XQ, Pan Q, Luo FL, et al. MiR-141 targets ZEB2 to suppress HCC progression. Tumour Biol. 2014; 35(10):9993–7. Crossref PMid:25008569
- Lin L, Liang H, Wang Y, Yin X, Hu Y, Huang J, et al. microRNA-141 inhibits cell proliferation and invasion and promotes apoptosis by targeting hepatocyte nuclear factor-3β in hepatocellular carcinoma cells. BMC Cancer. 2014; 14:879. Crossref PMid:25425543 PMCid:PMC4289273
- Hu M, Xia M, Chen X, Lin Z, Xu Y, Ma Y, et al. MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells. Dig Dis Sci. 2010; 55(8):2365–72. Crossref PMid:19830559
- Ding L, Yu LL, Han N, Zhang BT. miR-141 promotes colon cancer cell proliferation by inhibiting MAP2K4. Oncol Lett. 2017; 13(3):1665–71. Crossref PMid:28454307 PMCid:PMC5403415
- Li JZ, Li J, Wang HQ, Li X, Wen B, Wang YJ. MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression. Biochem Biophys Res Commun. 2017; 482(4):1381–6. Crossref PMid:27956179
- Brase JC, Johannes M, Schlomm T, Fälth M, Haese A, Steuber T, et al. Circulating miRNAs are correlated with tumor progression in prostate cancer. Int J Cancer. 2011; 128(3):608–16. Crossref PMid:20473869
- Xiao J, Gong AY, Eischeid AN, Chen D, Deng C, Young CY, et al. miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate. 2012; 72(14):1514–22. Crossref PMid:22314666
- Wang XL, Xie HY, Zhu CD, Zhu XF, Cao GX, Chen XH, et al. Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer. Tumour Biol. 2015; 36(2):877–83. Crossref PMid:25304156
- Mahdavinezhad A, Mousavi-Bahar SH, Poorolajal J, Yadegarazari R, Jafari M, Shabab N, et al. Evaluation of miR141, miR-200c, miR-30b expression and clinicopathological features of bladder cancer. Int J Mol Cell Med. 2015; 4(1):32–9. PMid:25815280 PMCid:PMC4359703
- van Jaarsveld MT, Helleman J, Boersma AW, van Kuijk PF, van Ijcken WF, Despierre E, et al. miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene. 2013; 32(36):4284–93. Crossref PMid:23045278
- Chen JL, Chen F, Zhang TT, Liu NF. Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues. Int J Mol Med. 2016; 37(6):1601–10. Crossref PMid:27081781
- Mateescu B, Batista L, Cardon M, Gruosso T, de Feraudy Y, Mariani O, et al. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 2011; 17(12):1627–35. Crossref PMid:22101765
- Li P, Xu T, Zhou X, Liao L, Pang G, Luo W, et al. Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: Involvement of ANP32E targeting. Cancer Med. 2017; 6(3):662–72. Crossref PMid:28220627 PMCid:PMC5345683
- Choi SK, Kim HS, Jin T, Hwang EH, Jung M, Moon WK. Overexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3K/AKT signaling pathways by secreting VEGF-A. BMC Cancer. 2016; 16:570. Crossref PMid:27484639 PMCid:PMC4969651
- Finlay-Schultz J, Cittelly DM, Hendricks P, Patel P, Kabos P, Jacobsen BM, et al. Progesterone downregulation of miR141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2015; 34(28):3676–87. Crossref PMid:25241899 PMCid:PMC4369481
- Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, Andersen H, et al. SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell–cell junctions. Nucleic Acids Research. 2005; 33(20):6566–78. Crossref PMid:16314317 PMCid:PMC1298926
- Tang K, Xu H. Prognostic value of meta-signature miRNAs in renal cell carcinoma: An integrated miRNA expression profiling analysis. Scientific Reports. 2015; 5:10272. Crossref PMid:25974855 PMCid:PMC4431463
- Chen X, Wang X, Ruan A, Han W, Zhao Y, Lu X, et al. miR-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression. Clin Cancer Res. 2014; 20(10):2617–30. Crossref PMid:24647573
- Walworth NC. Cell-cycle checkpoint kinases: Checking in on the cell cycle. Curr Opin Cell Biol. 2000; 12(6):697–704. Crossref
- Tricoli JV, Jacobson JW. MicroRNA: Potential for cancer detection, diagnosis, and prognosis. Cancer Res. 2007; 67(10):4553–5. Crossref PMid:17510380
- Macha MA, Seshacharyulu P, Krishn SR, Pai P, Rachagani S, Jain M, et al. MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers. Curr Pharm Des.2014; 20(33):5287–97. Crossref PMid:24479799 PMCid:PMC4113605
- Fendler A, Stephan C, Yousef GM, Kristiansen G, Jung K. The translational potential of microRNAs as biofluid markers of urological tumours. Nat Rev Urol. 2016; 13(12):734–52. Crossref PMid:27804986
- Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9(6):654–9. Crossref PMid:17486113
- Zheng H, Liu JY, Song FJ, Chen KX. Advances in circulating microRNAs as diagnostic and prognostic markers for ovarian cancer. Cancer Biology and Medicine. 2013; 10(3):123–30. PMid:24379986 PMCid:PMC3860338
- Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008; 105(30):10513–8. Crossref PMid:18663219 PMCid:PMC2492472
- Gonzales JC, Fink LM, Goodman OB Jr, Symanowski JT, Vogelzang NJ, Ward DC. Comparison of circulating MicroRNA 141 to circulating tumor cells, lactate dehydrogenase, and prostate-specific antigen for determining treatment response in patients with metastatic prostate cancer. Clin Genitourin Cancer. 2011; 9(1):39–45. Crossref PMid:21723797
- Antolín S, Calvo L, Blanco-Calvo M, Santiago MP, LorenzoPati-o MJ, Haz-Conde M, et al. Circulating miR-200c and miR-141 and outcomes in patients with breast cancer. BMC Cancer. 2015; 15:297. Crossref PMid:25885099 PMCid:PMC4405843
- Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, Nykter M, et al. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One. 2011; 6(3):e17745. Crossref PMid:21445232 PMCid:PMC3060165
- The Major Molecular Causes of Familial Hypercholesterolemia
Authors
1 Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 2 (2018), Pagination: 60-68Abstract
Familial Hypercholesterolemia (FH) is a common dominant disorder of cholesterol metabolism characterized by elevated serum cholesterol level which results in increasing risk of many diseases. The major cause of FH is the loss-of-function in Low Density Lipoprotein Receptor (LDLR), Apolipoprotein B-100 (ApoB-100), Low Density Lipoprotein Receptor Adapter Protein (LDLRAP1), and Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) gene that revealed to the defects in the uptake and degradation of Low Density Lipoprotein (LDL) via the LDLR pathway. In this review, we have highlighted the molecular disorder in LDLR, ApoB-100, LDLRAP1 and PCSK gene, leading to the possible accession on early diagnosis, screening of FH based on the clinical characteristics, family history, evaluated LDL-Cholesterol levels and recently genetic testing aided, hence molecular based therapy will be applied or recommended to FH patients.Keywords
Apolipoprotein B-100 (ApoB-100), Familial Hypercholesterolemia, Low Density Lipoprotein Receptor, Low Density Lipoprotein Receptor Adapter Protein, Proprotein Convertase Subtilisin/Kexin Type 9.References
- Najam O, Ray KK. Familial hypercholesterolemia: A review of the natural history, diagnosis, and management. Cardiol Ther. 2015; 4(1):25–38. Crossref PMid:25769531 PMCid:PMC4472649
- Soutar AK, Naoumova RP. Mechanisms of disease: Genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med. 2007; 4(4):214–25. Crossref PMid:17380167
- Farrokhi E, Shayesteh F, Asadi Mobarakeh S, Roghani Dehkordi F, Ghatreh Samani K, Hashemzadeh Chaleshtori M. Molecular characterization of Iranian patients with possible familial hypercholesterolemia. Indian J Clin Biochem. 2011; 26(3):244–8. Crossref PMid:22754187 PMCid:PMC3162949
- Khachadurian AK. The inheritance of essential Familial Hypercholesterolemia. Am J Med. 1964; 37:402–7. Crossref
- Williams RR, Hunt SC, Schumacher MC, Hegele RA, Leppert MF, Ludwig EH, et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol. 1993; 72(2):171–6. Crossref
- Séguro F, Bongard V, Bérard E, Taraszkiewicz D, Ruidavets JB, Ferrières J. Dutch lipid clinic network low-density lipoprotein cholesterol criteria are associated with long-term mortality in the general population. Arch Cardiovasc Dis. 2015; 108(10):511–8. Crossref PMid:26073227
- Goldstein JL, Brown MS. Molecular medicine. The cholesterol quartet. Science. 2001; 292(5520):1310–2. Crossref
- Varret M, Abifadel M, Rabès JP, Boileau C. Genetic heterogeneity of autosomal dominant hypercholesterolemia. Clin Genet. 2008; 73(1):1–13. Crossref PMid:18028451
- Hopkins PN, Toth PP, Ballantyne CM, Rader DJ. National lipid association expert panel on familial hypercholesterolemia. Familial hypercholesterolemias: Prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. 2011(3 Suppl); 5:S9– 17. Crossref PMid:21600530
- Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, et al. Familial defective Apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. J Lipid Res. 1990; 31(8):1337– 49. PMid:2280177
- Walldius G, Jungner I, Holme I, Aastveit AH, Kolar W, Steiner E. High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. Lancet. 2001; 358(9298):2026–33. Crossref
- Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003; 34(2):154–6. Crossref PMid:12730697
- 13. Banaszak LJ, Ranatunga WK. The assembly of apoBcontaining lipoproteins: A structural biology point of view. Ann Med. 2008; 40(4):253–67. Crossref PMid:18428019
- Horton JD, Cohen JC, Hobbs HH. PCSK9: A convertase that coordinates LDL catabolism. J Lipid Res. 2009; 50(Suppl):S172–7. Crossref PMid:19020338 PMCid:PMC2674748
- Brown MS, Goldstein JL. Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proc Natl Acad Sci U S A. 1974; 71(3):788–92. Crossref
- Francke U, Brown MS, Goldstein JL. Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease. Proc Natl Acad Sci U S A. 1984; 81(9):2826– 30. Crossref PMid:6326146 PMCid:PMC345163
- Lindgren V, Luskey KL, Russell DW, Francke U. Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes. Proc Natl Acad Sci U S A. 1985; 82(24):8567– 71. Crossref PMid:3866240 PMCid:PMC390958
- Usifo E, Leigh SE, Whittall RA, Lench N, Taylor A, Yeats C, et al. Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment. Ann Hum Genet. 2012; 76(5):387–401. Crossref PMid:22881376
- Arráiz N, Bermúdez V, Rondon N, Reyes F, Borjas L, Solís E, et al. Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population. Am J Ther. 2010; 17(3):325–9. Crossref PMid:20019594
- Neff D, Ruschitzka F, Hersberger M, Enseleit F, Hürlimann D, Noll G, et al. Detection of a novel exon 4 low-density lipoprotein receptor gene deletion in a swiss family with severe familial hypercholesterolemia. Clin Chem Lab Med. 2003; 41(3):266–71. Crossref PMid:12705331
- Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annu Rev Genet. 1990; 24:133–70. Crossref PMid:2088165
- Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat. 1992; 1:445–66. Crossref PMid:1301956
- Varghese MJ. Familial hypercholesterolemia: A review. Annals of Pediatric Cardiology. 2014; 7(2):107–17. Crossref PMid:24987256 PMCid:PMC4070199
- Knott TJ, Rall SC Jr, Innerarity TL, Jacobson SF, Urdea MS, Levy-Wilson B, et al. Human apolipoprotein B: Structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization. Science. 1985; 230(4721):37– 43. Crossref PMid:2994225
- Law SW, Lackner KJ, Hospattankar AV, Anchors JM, Sakaguchi AY, Naylor SL, et al. Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2. Proc Natl Acad Sci U S A. 1985; 82(24):8340–4. Crossref PMid:3001697 PMCid:PMC390911
- Soria LF, Ludwig EH, Clarke HR, Vega GL, Grundy SM, Mc Carthy BJ. Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100. Proc Natl Acad Sci U S A. 1989; 86(2):587–91. Crossref PMid:2563166 PMCid:PMC286517
- Dunning AM, Houlston R, Frostegård J, Revill J, Nilsson J, Hamsten A, et al. Genetic evidence that the putative receptor binding domain of apolipoprotein B (residues 3130 to 3630) is not the only region of the protein involved in interaction with the low density lipoprotein receptor. Biochim Biophys Acta. 1991; 1096(3):231–7. Crossref
- Gaffney D, Reid JM, Cameron IM, Vass K, Caslake MJ, Shepherd J, et al. Independent mutations at codon 3500 of the apolipoprotein B gene are associated with hyperlipidemia. Arterioscler Thromb Vasc Biol. 1995; 15(8):1025–9. Crossref PMid:7627691
- Pullinger CR, Hennessy LK, Chatterton JE, Liu W, Love JA, Mendel CM, et al. Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity. J Clin Invest. 1995; 95(3):1225–34. Crossref PMid:7883971 PMCid:PMC441461
- Borén J, Ekström U, Agren B, Nilsson-Ehle P, Innerarity TL. The molecular mechanism for the genetic disorder familial defective apolipoprotein B100. J Biol Chem. 2001; 276(12):9214–8. Crossref PMid:11115503
- Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science. 2001; 292(5520):1394–8. Crossref PMid:11326085
- Sun XM, Patel DD, Acosta JC, Gil J, Soutar AK. Premature senescence in cells from patients with Autosomal Recessive Hypercholesterolemia (ARH): Evidence for a role for ARH in mitosis. Arterioscler ThrombVasc Biol. 2011; 31(10):2270–7. Crossref PMid:21778424
- Soutar AK, Naoumova RP. Autosomal Recessive Hypercholesterolemia. Semin Vasc Med. 2004; 4(3):241–8. Crossref PMid:15630633
- Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, et al. A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene. Atherosclerosis. 2011; 219(2):663–6. Crossref PMid:21872251
- Horton JD, Cohen JC, Hobbs HH. Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci. 2007; 32(2):71–7. Crossref PMid:17215125 PMCid:PMC2711871
- Peterson AS, Fong LG, Young SG. PCSK9 function and physiology. J Lipid Res. 2008; 49(6):1152–6. Crossref PMid:18375913 PMCid:PMC2386899
- Hartgers ML, Ray KK, Hovingh GK. New approaches in detection and treatment of familial hypercholesterolemia. Curr Cardiol Rep. 2015; 17(12):109. Crossref PMid:26482752 PMCid:PMC4611021
- Stancu C, Sima A. Statins: mechanism of action and effects. J Cell Mol Med. 2001; 5(4):378–87. Crossref PMid:12067471
- Endo A. A historical perspective on the discovery of statins. Proc Jpn Acad Ser B Phys Biol Sci. 2010; 86(5):484–93. Crossref PMid:20467214 PMCid:PMC3108295
- Wong E, Goldberg T. Mipomersen (kynamro): A novel antisense oligonucleotide inhibitor for the management of homozygous familial hypercholesterolemia. P T. 2014; 39(2):119–22.
- Agarwala A, Jones P, Nambi V. The role of antisense oligonucleotide therapy in patients with familial hypercholesterolemia: risks, benefits, and management recommendations. Curr Atheroscler Rep. 2015; 17(1):467. Crossref PMid:25398643
- Jamil H, Dickson JK Jr, Chu CH, Lago MW, Rinehart JK, Biller SA, et al. Microsomal triglyceride transfer protein. Specificity of lipid binding and transport. J Biol Chem. 1995; 270(12):6549–54. Crossref PMid:7896791
- Davis KA, Miyares MA. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014; 71(12):1001–8. Crossref PMid:24865757
- Zimmerman MP. How do PCSK9 inhibitors stack up to statins for low-density lipoprotein cholesterol control? American Health and Drug Benefits. 2015; 8(8):436–42. PMid:26702335 PMCid:PMC4684634
- Paton DM. PCSK9 inhibitors: Monoclonal antibodies for the treatment of hypercholesterolemia. Drugs Today (Barc). 2016; 52(3):183–92. Crossref PMid:27186592
- Chaudhary R, Garg J, Shah N, Sumner A. PCSK9 inhibitors: A new era of lipid lowering therapy. World J Cardiol.2017; 9(2):76–91. Crossref PMid:28289523 PMCid:PMC5329749
- Burke AC, Dron JS, Hegele RA, Huff MW. PCSK9: Regulation and target for drug development for dyslipidemia. Annu Rev Pharmacol Toxico. 2017; 57:223–44. Crossref PMid:27575716
- The Prognosis Value of CDH-1 Methylation-The Epigenetic Biomarker in Nasopharyngeal Carcinoma:Systematic Review and Meta-Analysis
Authors
1 Faculty of Biotechnology, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City − 700000, VN
2 Faculty of Biology and Biotechnology, Ho Chi Minh City University of Science, Hồ Chí Minh − 700000, VN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 11, No 2-4 (2019), Pagination: 68-74Abstract
Background: The phenome of CDH-1 gene methylation has been reported to be associated with the nasopharyngeal tumorigenesis. Objective: Aiming to evaluate the association between the CDH-1 gene methylation and nasopharyngeal cancer, and its correlation could be used as an epigenetic biomarker for nasopharyngeal cancer risk based on meta-analysis. Materials and Methods: Relevant articles were identified by searching MEDLINE database. The frequency and Odds Ratio (OR) were applied to estimate the effect of CDH-1 methylation based on random-/fix-effects models. Results: Total of 12 studies, including 500 samples from NPC patients and 201 samples from non-cancerous samples, were enrolled in current study. Overall, the frequency of CDH-1 gene methylation were 48.50% and 3.09% in the case and control group, respectively. The association between the CDH-1 gene methylation and risk of NPC was also confirmed by calculating OR value of 15.33 (95% CI = 7.82-30.06), based on the fix-effects model. Additionally, the significant association was also found between the methylation of CDH-1 gene and subgroups. Conclusion: this meta-analysis provides scientific evidences to suggest the CDH-1 methylation was the potential biomarker for risk of NPC.Keywords
CDH-1, Epigenetic Biomarker, Nasopharyngeal carcinoma, Meta-Analysis.References
- Sham JS, Wei WI, Zong YS, Choy D, Guo YQ, Luo Y, et al. Detection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsy. Lancet 1990; 335(8686):371-74. https://doi.org/10.1016/01406736(90)90206-K
- Chang CM, Yu KJ, Mbulaiteye SM, Hildesheim A, Bhatia K. The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: A need for reappraisal. Virus Res. 2009; 143(2):209-21. https://doi.org/10.1016/j.virusres.2009.07.005. PMid: 19596032, PMCid: PMC2731007.
- Mahdavifar N, Ghoncheh M, Mohammadian-Hafshejani A, Khosravi B, Salehiniya H. Epidemiology and inequality in the incidence and mortality of Nasopharynx Cancer in Asia. Osong. Public Health Res. Perspect. 2016; 7(6):360-72. https:// doi.org/10.1016/j.phrp.2016.11.002. PMid: 28053841, PMCid: PMC5194228.
- Lao TD, Nguyen TV, Nguyen DH, Nguyen MT, Nguyen CH, Le THA. miR-141 is up-regulated in biopsies from Vietnamese patients with nasopharyngeal carcinoma. Braz. Oral. Res. 2018a; 32:e126. https://doi.org/10.1590/1807-3107bor-2018.vol32.0126. PMid: 30569973.
- Lao TD, Nguyen DH, Le THA. Study of mir-141 and its potential targeted mRNA PTEN expression in Nasopharyngeal Carcinoma: From in Silico to initial experiment analysis. AJPRHC. 2018b; 10(3):66-74. https://doi.org/10.18311/ajprhc/2018/22341.
- Lao TD, Le THA. Epidemiology, incidence and mortality of Nasopharynx Cancer in Southeast Asia: An update report. Adv. Life Sci. 2020; 7(2):86-90.
- Wang LH, Wu CF, Rajasekaran N, Shin YK. Loss of tumor suppressor gene function in human cancer: An Overview. Cell Physiol. Biochem. 2018; 51(6):2647-93. https://doi.org/10.1159/000495956. PMid: 30562755.
- Goodwin M, Yap AS. Classical cadherin adhesion molecules: Coordinating cell adhesion, signaling and the cytoskeleton. J. Mol. Histol. 2004; 35:839-44. https://doi.org/10.1007/s10735004-1833-2. PMid: 15609097.
- Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: How does cadherin dysfunction promote tumor progression? Oncogene. 2008; 27(55):6920-29. https://doi.org/10.1038/ onc.2008.343. PMid: 19029934, PMCid: PMC2745643.
- Moher D, Liberati A, Tetzlaff J, Altman DG, Altman D, Antes G, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009; 6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097. PMid: 19621072, PMCid: PMC2707599.
- Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002; 21(11):1539-58. https://doi.org/10.1002/sim.1186. PMid: 12111919.
- DerSimonian R. Meta-analysis in the design and monitoring of clinical trials. Stat. Med. 1996; 15(12):1237-48. https://doi.org/10.1002/(SICI)1097-0258(19960630)15:12<1237::AIDSIM301> 3.0.CO;2-N.
- Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414):557-60.https://doi.org/10.1136/bmj.327.7414.557 PMid: 12958120, PMCid: PMC192859.
- Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088101. https://doi.org/10.2307/2533446. PMid: 7786990.
- Egger M, Davey SG, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. https://doi.org/10.1136/bmj.315.7109.629. PMid: 9310563, PMCid: PMC2127453.
- Chang HW, Chan A, Kwong DLW, Wei WI, Sham JST, Yuen APW. Evaluation of Hypermethylated tumor suppressor genes as tumor markers in mouth and throat rinsing fluid, nasopharyngeal swab and peripheral blood of nasopharygeal carcinoma patient. Int. J. Cancer. 2003; 105:851-55. https://doi.org/10.1002/ijc.11162. PMid: 12767073.
- Wong TS, Tang KC, Kwong DLW, Sham JST, Wei WI, Kwong YL, et al. Differential gene methylation in undifferentiated nasopharyngeal carcinoma. International Journal of Oncology. 2003; 22:869-74. https://doi.org/10.3892/ijo.22.4.869.
- Tsao SW, Liu Y, Wang XX, Yuen PW, Leung SY, Yuen ST, et al. The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells. European Journal of Cancer. 2003; 39:524-31. https://doi.org/10.1016/S0959-8049(02)00494-X.
- Li Z, Lin SX, Liang YJ. Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells. Europe PMC. 2003; 25(3):238-42.
- Li Z, Lin S, Liang YJ. Detection of gene promoter methylation and mRNA, protein expression levels of E-cadherin in nasopharyngeal carcinoma. Springer. 2003; 32(1):25.30. PMID:12760799
- Wong TS, Kwong DLW, Sham JST, Wei WI, Kwong YL, Yuen APW. Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. Clinical Cancer Research. 2004; 10:2401-06. https://doi.org/10.1158/10780432.CCR-03-0139. PMid: 15073117.
- Li Z, Ren Y, Lin SX, Liang YJ, Liang HZ. Association of E-cadherin and beta-catenin with metastasis in nasopharyngeal carcinoma. Europe PMC. 2004; 117(8):1232-39.
- Tan SH, Ida H, Goh BC, Hsieh W, Loh M, Ito Y. Analyses of promoter hypermethylation for RUNX3 and other tumor suppressor genes in nasopharyngeal carcinoma. Anticancer Research. 2006; 26:4287-92.
- Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J. Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma. Cancer Detection and Prevention. 2008; 32:127-34. https://doi.org/10.1016/j.cdp.2008.05.005. PMid:18632221.
- Ayadi W, Karray-Hakim H, Khabir A, Feki L, Charfi S, Boudawara T, et al. Aberrant methylation of p16, DLEC1, BLU and E-Cadherin gene promoters in nasopharyngeal carcinoma biopsies from tunisian patients. Anticancer Research. 2008; 28:2161-68.
- Ran Y, Wu S, You Y. Demethylation of E-cadherin gene in nasopharyngeal carcinoma could serve as a potential therapeutic strategy. J. Biochem. 2011; 149(1):49-54. https://doi.org/10.1093/jb/mvq128.PMid: 21059597.
- Challouf S, Ziadi S, Zaghdoudi R, Ksiaa F, Ben Gacem R, Trimeche M. Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients. Clinica. Chimica. Acta. 2012; 413:795-802. https://doi.org/10.1016/j.cca.2012.01.018. PMid: 22296674.
- Li LL, Shu XS, Wang ZH, Cao Y, Tao Q. Epigenetic disruption of cell signaling in nasopharyngeal carcinoma. Chin. J. Cancer. 2011; 30(4):231-39. https://doi.org/10.5732/cjc.011.10080 PMid: 21439244, PMCid: PMC4013349.
- Jiang W, Cai R, Chen QQ. DNA Methylation biomarkers for nasopharyngeal carcinoma: Diagnostic and prognostic tools. Asian Pac. J. Cancer Prev. 2015; 16(18):8059-65. https://doi.org/10.7314/APJCP.2015.16.18.8059. PMid: 26745039.
- Semb H, Christofori G. The tumor-suppressor functions of E-cadherin. Am. J. Hum. Genet. 1998; 63(6):1588-93. https://doi.org/10.1086/302173. PMid: 9837810, PMCid: PMC1377629.
- Pećina-Slaus N. Tumor suppressor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int. 2003; 3(1):17. https://doi.org/10.1186/1475-2867-3-17 PMid: 14613514, PMCid: PMC270068.
- Huang Z, Bassil CF, Murphy SK. Methylation-specific PCR. Methods Mol. Biol. 2013; 1049:75-82. https://doi.org/10.1007/978-1-62703-547-7_7. PMid: 23913210.
- Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Vinciguerra M. DAPK1 promoter Methylation and cervical cancer risk: A systematic review and a meta-analysis. PLoS One. 2015; 10(8):e0135078. https:// doi.org/10.1371/journal.pone.0135078. PMid: 26267895, PMCid: PMC4534406.
- Epidemiology, Incidence, Mortality of Cervical Cancer in Southeast Asia and their Relationship: An Update Report
Authors
1 Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 12, No 3 (2020), Pagination: 97-101Abstract
Cervical cancer is the leading-caused cancer death in women worldwide, especially occurring in the developing countries. The understanding of the incidence, mortality, and their relationship with the Human Development Index (HDI) and its three dimensions, including gross national income per capita, education index, and life expectancy, is crucial to establish the best way to prevent the increasing of cervical cancer in future. The data of the incidence (-ASR), mortality (-ASR), HDI were extracted from the GLOBOCAN and Human Development Reports database. Person Correlation Coefficient was applied to characterize the relationship among them. The incidence and mortality of Cervical Cancer in Southeast Asia (total new cases: 62,456 cases, counting for 19, 81%; new death cases: 35,738, counting for 21.22%), ranked in the top three of Asian regions. There was the negative correlation between the incidence-ASR, mortality-ASR with HDI, and its three dimensions. A significant correlation between the mortality-ASR rate of cervical cancer and Life expectancy at birth was recorded. The cancer of cervix gravitates to Asian region, including Southeast Asian countries. There was a significant relationship between the mortality-ASR rate of cervical cancer and Life expectancy at birth.
Keywords
Cervical Cancer, Incidence, Mortality, Southeast Asia.References
- Sherris J, Herdman C, Elias C. Cervical cancer in the developing world. West J. Med. 2001; 175(4):231-33. https://doi.org/10.1136/ewjm.175.4.231. PMid: 11577044, PMCid: PMC1071564.
- Wong LP. Knowledge and attitudes about HPV infection, HPV vaccination, and cervical cancer among rural Southeast Asian Women. Int. J. Behav. Med. 2011; 18(2):105-11. https://doi.org/10.1007/s12529-010-9104-y. PMid: 20524163.
- Mohanty G, Ghosh SN. Risk factors for cancer of cervix, status of screening and methods for its detection. Arch. Gynecol. Obstet. 2015; 291(2):247-49. https://doi.org/10.1007/s00404-014-3492-1. PMid:25273981.
- Muñoz N, Bosch FX, De Sanjosé S, et al. Epidemiologic classification of human Papillomavirus types associated with cervical cancer. N. Engl. J. Med. 2003; 348(6):518-27. https://doi.org/10.1056/NEJMoa021641. PMid: 12571259.
- Lao D, Le H. Epidemiology, incidence and mortality of Nasopharynx Cancer in Southeast Asia: An update report. Adv. Life Sci. 2020; 7(2):86-90.
- Bray F, Jemal A, Grey N, Ferlay J., Forman, D. Global cancer transitions according to the Human Development Index (2008-2030): A population-based study. Lancet Oncol. 2012; 13(8):790-01. https://doi.org/10.1016/S14702045(12)70211-5.
- Soheylizad M, Khazaei S, Jenabi E, Delpisheh A, Veisani Y. The relationship between human development index and its components with thyroid cancer incidence and mortality: Using the decomposition approach. Int. J. Endocrinol. Metab. 2018; 16(4):e65078. https://doi.org/10.5812/ijem.65078. PMid: 30464773, PMCid: PMC6218660.
- Mahdavifar N, Towhidi F, Makhsosi BR, et al. Incidence and mortality of Nasopharynx cancer and its relationship with human development index in the world in 2012. World J. Oncol. 2016; 7(5-6):109-18. https://doi.org/10.14740/wjon980w. PMid:28983375 PMCid:PMC5624652.
- Cancer Today. Cancer Fact sheet. Accessed 12th December, 2019. Available from https://gco.iarc.fr/today/fact-sheetscancers.
- United Nations Development Programme. Human Development Data (1990-2018). Accessed 12th December 2019. Available from http://hdr.undp.org/en/data.
- Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis. Lancet Glob Heal, 2020; 8(2):e191-03. https://doi.org/10.1016/S2214-109X(19)30482-6.
- Momenimovahed Z, Salehiniya H. Incidence, mortality and risk factors of cervical cancer in the world. Biomed. Res. Ther. 2017; 4(12):1795-811. https://doi.org/10.15419/bmrat.v4i12.386.