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Asian Journal of Pharmaceutical Research and Health Care, Vol 5, No 2 (2013), Pagination: 43-51
Abstract
The present paper describes simple, accurate, rapid, precise and sensitive UV spectrophotometric absorption correction method for the simultaneous determination of amlodipine and aliskiren in combined tablet dosage form. methanol was used as solvent. The wavelengths selected for the analysis using absorption correction method were 354.5 nm and 256.0 nm for estimation of amlodipine and aliskiren respectively. Beer's law obeyed in the concentration range of 10-60 μg/mL and 20-120 μg/mL for amlodipine and aliskiren, respectively. The mean percentage drug content for amlodipine and aliskiren were found to be 99.9. ± 1.38 and 99.87 ± 1.25 respectively and the % RSD value was found to be less than 2 which shows the precision of method. The high recovery and low coefficients of variation conforms the suitability for the routine quality control analysis of amlodipine and aliskiren in pure and pharmaceutical dosage forms.
Keywords
Amlodipine, Aliskiren, Spectrophotometric Absorption Correction Method.
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