Abstract Views :243 |
PDF Views:115
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Ternopil State Medical University
named after I. Ya. Horbachevsky, Ternopil, UA
2 Department of Research Forensic Centre at the Ministry of Internal Affairs of
Ukraine in Ternopil Region, Ternopil, UA
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 8, No 2 (2016), Pagination: 62-66
Abstract
Methods for the quantitative determination of loratadine tablets by differential spectrophotometry and photo-colorimetry have been developed. During the procedure parameters (range of application methods, stability, specificity, robasnist, convergence, internal laboratory accuracy (precision), accuracy, reproducibility) have been considered. The results indicate that the method photo-colorimetry has not met modern criteria for analytical methods for quantitative determination of parameters such as stability, accuracy and linearity, so other validation parameters (robasnist, convergence and inter-laboratory precision) have been determined only by spectrophotometric methods. It is found that the technique of quantitative determination of loratadine by differential spectrophotometry is accurate, correct, reproducible and linear, to determine its suitability for use in pharmaceutical analysis.
Keywords
Differential Spectrophotometry, Loratadine Tablets, Photo-Colorimetry, Quantitative Detection, Validation.
Full Text
