Antifilarial Activity of Plumeria Alba Linn Bark

The aqueous extract of Bark of Plumeria. alba was tested for its effect on the spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m) complex of Setaria cervi a cattle filarial parasite, and on the survival of microfilariae . The aqueous extract could inhibit the spontaneous movements of S.cervi , characterized by initial stimulation followed by reversible paralysis. The concentration required to produce similar effect on nerve muscle complex was less as compared to the whole worm. The lethal concentration 50 (LC ₅₀ ) and lethal concentration 90 (LC ₉₀ ) for aqueous extract were 80 ng/ml and 105 ng/ml respectively.