Screening of Synthetic New Heterocyclic Derivatives of 3-Formyl-4-Hydroxycoumarin for Anti-Inflammatory Activity in Albino Rats

Coumarins have multiple biological activities; various coumarin-r elated derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase pathways of arachidonate metabolism. Several natural or synthetic coumarins with various hy droxyl and other substitutes were found to inhibit lipid peroxidation and to scavenge hydroxyl ra dical and superoxide anion and to influence processes involving free radical mediated injury. The heterocyclic derivatives of 3-formyl-4-hydoxycoumarin were found to present significant anti-infl ammatory effect, the compounds inhibited formalin induced hind paw edema and they also signifi cantly suppressed the formation of granuloma tissue in cotton pellet induced chronic model of inflammation. The result showed that the anti-inflammatory (both acute & chronic) effect of the test compound Ib is comparable to that of standard Antiinflammatory drug Diclofenac Sodium.