Asian Journal of Chemistry and Pharmaceutical Sciences

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Application of Sequential Design of Experiments to Develop Ibuprofen (400 mg) Tablets by Direct Compression


Affiliations
1 School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico, Mexico
2 Biokinetics, S.A. de C.V., Mexico City, Mexico, Mexico
 

A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.

Keywords

Central-Composite Design, Design Of Experiments, Direct Compression, Ibuprofen, Simplex-Screening Design.
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  • Application of Sequential Design of Experiments to Develop Ibuprofen (400 mg) Tablets by Direct Compression

Abstract Views: 458  |  PDF Views: 214

Authors

Socorro Alpizar-Ramos
School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico, Mexico
Mario González-de la Parra
Biokinetics, S.A. de C.V., Mexico City, Mexico, Mexico

Abstract


A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.

Keywords


Central-Composite Design, Design Of Experiments, Direct Compression, Ibuprofen, Simplex-Screening Design.

References