Toxicology International (Formerly Indian Journal of Toxicology)

Chanda D. ¹, Das S. K. ², Kundu A. ², Chakraborty A. K. ², Mandal T. K. ², Basak D. K. ³, Suaib Luqman ¹

Affiliations
1 Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226015, IN
2 Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252, IN
3 Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252, IN

Abstract

A non-toxic dose of metamitron (triazine herbicide) was determined in black Bengal goats by trial and error. Hematological parameters like total count, Hb percentage, ESR, biochemical parameters like blood sugar, pyruvic acid, LDH, AChE and tissue biochemical parameters like ALT, AST activity, reduced glutathione level and lipid peroxidation level were estimated in black Bengal goats after oral administration of a single dose of metamitron @30 mg/kg body weight (b.wt.). Histopathological studies were also carried out in tissue sections of liver, kidney, spleen, thyroid, heart and brain. No significant changes were found in experimental subjects when compared to control indicating that metamitron @30 mg/kg b.wt. may be a non-toxic dose to goats and can be used safely in agricultural field.

Keywords

Glutathione, goat, lipid peroxidation, metamitron, toxicity, triazine herbicide

Full Text