Toxicology International (Formerly Indian Journal of Toxicology)

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Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats


Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
2 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana, India
3 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana, India
     

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The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.

Keywords

Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats.
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  • Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats

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Authors

Y. Ravikumar
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
D. Madhuri
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
M. Lakshman
Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
A. Gopala Reddy
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana, India
B. Kalakumar
Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana, India

Abstract


The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.

Keywords


Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats.

References





DOI: https://doi.org/10.18311/ti%2F2020%2Fv27i1%262%2F25279