Toxicology International (Formerly Indian Journal of Toxicology)

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Therapeutic Role of Mitochondria Targeted Curcumin against Pseudomonas aeruginosa Induced Oxidative Stress in Thyroid Gland of Female Swiss albino Mice


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1 Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh, India
     

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Bacteria are found universally and contaminate the soil, air and water. Through contaminated air, water and soil bacteria reach inside the body and causes immense harm. The problem of thyroid is that, it affects the public health worldwide. The main purpose of this investigation is to find out the toxic effects of Pseudomonas aeruginosa on thyroid gland and preventive role of mitochondria targeted curcumin in bacterial induced thyroid toxicity in female Swiss albino mice. The animals are separated in different groups. Group I served as control and Group II administered with effective dose of Pseudomonas aeruginosa. Group III co-treated with mitochondria targeted curcumin for the period of 14 days. With the completion of treatment period blood serum and tissue samples were collected for determining the level of thyroid hormones and oxidative stress. In this investigation shows that mice exposed to bacteria have decreased T3 and T4 concentration as compared to control and co-treated mice have some elevated level of T3 and T4 hormones as compared to bacteria treated mice. In the biochemical study it is found that the increased lactate dehydrogenate, catalase activity, superoxide dismutase and lipid peroxidation and decreased glutathione reductase points towards the induced oxidative stress in thyroid gland. It is concluded that the exposure to Pseudomonas aeruginosa causes thyroid problem and treatment with mitochondria targeted curcumin prevents the induced toxicity.

Keywords

Mitochondria Targeted Curcumin, Pseudomonas aeruginosa, Thyroid Gland, T3, T4, TSH.
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  • Therapeutic Role of Mitochondria Targeted Curcumin against Pseudomonas aeruginosa Induced Oxidative Stress in Thyroid Gland of Female Swiss albino Mice

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Authors

Narendra Namdev
Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh, India
Arun Kumar
Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh, India
Gayatri Rai
Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh, India
Payal Mahobiya
Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh, India

Abstract


Bacteria are found universally and contaminate the soil, air and water. Through contaminated air, water and soil bacteria reach inside the body and causes immense harm. The problem of thyroid is that, it affects the public health worldwide. The main purpose of this investigation is to find out the toxic effects of Pseudomonas aeruginosa on thyroid gland and preventive role of mitochondria targeted curcumin in bacterial induced thyroid toxicity in female Swiss albino mice. The animals are separated in different groups. Group I served as control and Group II administered with effective dose of Pseudomonas aeruginosa. Group III co-treated with mitochondria targeted curcumin for the period of 14 days. With the completion of treatment period blood serum and tissue samples were collected for determining the level of thyroid hormones and oxidative stress. In this investigation shows that mice exposed to bacteria have decreased T3 and T4 concentration as compared to control and co-treated mice have some elevated level of T3 and T4 hormones as compared to bacteria treated mice. In the biochemical study it is found that the increased lactate dehydrogenate, catalase activity, superoxide dismutase and lipid peroxidation and decreased glutathione reductase points towards the induced oxidative stress in thyroid gland. It is concluded that the exposure to Pseudomonas aeruginosa causes thyroid problem and treatment with mitochondria targeted curcumin prevents the induced toxicity.

Keywords


Mitochondria Targeted Curcumin, Pseudomonas aeruginosa, Thyroid Gland, T3, T4, TSH.

References





DOI: https://doi.org/10.18311/ti%2F2020%2Fv27i1%262%2F24457