Toxicology International (Formerly Indian Journal of Toxicology)

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Effects on Oxidative Balance and Acetlycholinesterase in Liver and Brain of Rats Dermally Exposed to Bifenthrin


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, India
     

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The present study was aimed to appraise the oxidative stress potential of bifenthrin and its effects on acetylcholinesterase in liver and brain of wistar rats after its repeated dermal application for a period of 30 days. The rats were divided into four groups with six rats in each group. Group I and III served as control and were applied with distilled water @ 1.8ml/Kg/day where as the animals of group II and IV were dermally applied with bifenthrin @ 45mg/Kg/day for 20 and 30 days respectively. Significant increase in MDA levels was observed in liver and brain homogenates after 20th and 30th day of dermal treatment. Significant decrease in SOD was observed both in liver and brain after 20th and 30th day. GPx decreased significantly after 30th day in liver and after 20th and 30th day in brain. The activities of GST and CAT decreased significantly in liver and brain both after 20th and 30th days of dermal application. Non-significant decrease in AchE was observed in liver and brain homogenates.

Keywords

Bifenthrin, Liver, Brain, Oxidative Stress, Acetyl-Cholinesterase, Rats.
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  • Effects on Oxidative Balance and Acetlycholinesterase in Liver and Brain of Rats Dermally Exposed to Bifenthrin

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Authors

Muneer Ahmad Dar
Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, India
Arshad Hussain Mir
Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, India
Rajinder Raina
Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, India
Pawan Kumar Verma
Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, India

Abstract


The present study was aimed to appraise the oxidative stress potential of bifenthrin and its effects on acetylcholinesterase in liver and brain of wistar rats after its repeated dermal application for a period of 30 days. The rats were divided into four groups with six rats in each group. Group I and III served as control and were applied with distilled water @ 1.8ml/Kg/day where as the animals of group II and IV were dermally applied with bifenthrin @ 45mg/Kg/day for 20 and 30 days respectively. Significant increase in MDA levels was observed in liver and brain homogenates after 20th and 30th day of dermal treatment. Significant decrease in SOD was observed both in liver and brain after 20th and 30th day. GPx decreased significantly after 30th day in liver and after 20th and 30th day in brain. The activities of GST and CAT decreased significantly in liver and brain both after 20th and 30th days of dermal application. Non-significant decrease in AchE was observed in liver and brain homogenates.

Keywords


Bifenthrin, Liver, Brain, Oxidative Stress, Acetyl-Cholinesterase, Rats.

References





DOI: https://doi.org/10.22506/ti%2F2017%2Fv24%2Fi3%2F166502