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Tippavajhala, Vamshi Krishna
- A Review on In Situ Gel Forming Ophthalmic Drug Delivery Systems
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1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, IN
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 380-386Abstract
Nowadays ophthalmic route of administration of drugs is rapidly progressing and more studies are going on in formulating ophthalmic drug delivery systems. There are many conventional dosage forms available in the market like ointments, eye drops etc. The main drawback with these types of formulations is rapid drainage of the instilled dose due to the lacrimal fluid secretions and blinking of the eye lids. In order to minimize this drainage and to increase the ocular residence time and corneal contact time, in situ gel forming formulations are developed. In these systems sol to gel transformation takes place due to the environmental changes like pH, temperature, ionic strength. Some polymers like sodium alginate, HPMC are frequently used to initiate these processes. These formulations can be assessed for viscosity, clarity, gel strength, gelling capacity, gelling time, texture, isotonicity, sterility, ocular irritancy, anti-microbial efficacy, in vitro drug release, ex vivo release, in vivo absorption, in vivo retention and stability.Keywords
In Situ Gel Formulations, Ophthalmic Drug Delivery Systems.
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- Equipment Qualification of a New Laboratory Tray Dryer
Abstract Views :167 |
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Authors
Affiliations
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka, State, IN
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka, State, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 805-811Abstract
This qualification study deals with the Installation and Qualification of a New Tray Dryer. Granules in the pharmaceutical industry are dried using the different equipment like Fluid Bed Dryer, Belt Dryer, Tray Dryer, Vacuum Tray Dryer, Spray Dryer and Rotary Dryer. In this case, the study was conducted on the newly installed laboratory Tray Dryer. Various documentation requirements like User Requirement Specification, Factory Acceptance Test, Site Acceptance Test, Installation Qualification, Operational Qualification and Performance Qualification were carried out for the equipment. Calibration of measuring devices, the prepared granules were dried using the tray drier and noted the time required to dry the granules. Equipment qualification of newly installed laboratory Tray Dryer was performed meeting all the qualification parameters.Keywords
Tray Dryer, User Requirement Specification, Installation Qualification, Operational Qualification and Performance Qualification.References
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