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Abbas, Sawsan Khudhair
- Synthesis and Characterization New Heterocyclic Compounds Derivatives from Vanillin
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Authors
Affiliations
1 Department of Physiology and Pharmacology/College of Veterinary Medicine/University of Kerbala, IQ
2 Department of Chemistry, College of Sciences/University of Kerbala, IQ
1 Department of Physiology and Pharmacology/College of Veterinary Medicine/University of Kerbala, IQ
2 Department of Chemistry, College of Sciences/University of Kerbala, IQ
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1943-1946Abstract
In this article, some new heterocyclic derivatives, for example pyrimidine and pyrazoles were synthesized by reaction vanillin with paracetamol utilizing KOH as a catalyst to synthase 3-(4-hydroxy-3-methoxyphenyl)-N-(4- hydroxyphenyl)acrylamide(1).The compound (1) on react with Sodium azide, hydrazine, urea, and thiourea in the existence of acetic acid or KOH and ethanol as a catalyst to give (2,3,4,5) compounds. The reaction monitors by TLC. All synthesized compounds have been distinguished by melting point, IR, 1H.NMR spectroscopy.Keywords
Vanillin, Paracetamol, Heterocyclic.
References
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- Abbas F., Afak A., Ali., 2012. Synthesis, Characterization and Computational Study of Some New Heterocyclic Derived from 1-(biphenyl-4-yl)-3-(furan-2-yl)prop-2-en-1-one, Journal of Materials and Environmental Science 3 : 1071-1078.
- Analysis of Copper (II) in Pharmaceutical Products using Micelle form with the Turbidity Method
Abstract Views :190 |
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Authors
Affiliations
1 Chemistry Department, College of Science, University of Kerbala, Karbala, IQ
1 Chemistry Department, College of Science, University of Kerbala, Karbala, IQ
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2116-2122Abstract
A modern and easy procedure performed using the turbidity method for the pre-concentration and estimating of Cu (II) in pharmaceutical samples. The limited solubility complex formed by the reaction of copper ions with cysteine and SDS as the surfactant. The copper content measured using the turbidity method. The effect of chemical and physical parameters including grouping of the ligand, SDS, pH, equilibration temperature and time and effect of salting are studied. The analytical qualities of the technique have been determined, which includes linear range (the range was between 0.158 -47.625μgmL-1), the coefficient of turbidity (k=13.21), limit of detection (LOD=0.1767 μg ml-1nd LOQ=0.5355 μg mL-1).All values are calculated using statistical programs, but the detection limit for Cu(II) ions based on eight times the standard deviation of the blanks (N:8) characterized as 3Sb/m (where Sb is the standard deviation of the blank and m is the slope of the calibration curve) is 0.0096μg mL-1 (3σ). The method employed successfully for the determination of Cu2+ in different local pharmaceutical formations.Keywords
Copper in Pharmaceutical Products, Turbidity, Micelle.References
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