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Kaddoura, Sally
- The Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid profile in vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients
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Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1610-1614Abstract
Objective: This study aims to investigate the impact of combining calcium and vitamin D supplements with metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome (PCOS) women. Study design: A randomized, placebo-controlled clinical trial. Setting: Damascus University of Obstetrics and Gynecology Hospital and Orient Hospital, in Damascus, Syria. Materials and methods: Forty PCOS women with 25-hydroxyvitamin D<30 ng/mL were randomly assigned to take either metformin (1500 mg/daily) plus placebo or metformin (1500 mg/daily) plus calcium (1000 mg/daily) and vitamin D3 (6000 IU/daily) orally for 8 weeks. Fasting serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG) and non-HDL cholesterol (non-HDL) were detected at the baseline and after 8 weeks of intervention. Results: Of all participants, thirty-four completed the study. After 8 weeks of intervention, calcium and vitamin D levels increased significantly in the supplementation group, but no significant changes in the lipid profile were noticed in both groups. Conclusions: Adding calcium and vitamin D to metformin therapy had no superior effect on improving lipid profile in vitamin D deficient/insufficient subjects with PCOS.Keywords
Polycystic Ovary Syndrome, Lipid Profile, Calcium, Vitamin D, Metformin.
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