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Madhan Kumar, S. J.
- Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats
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Authors
Saminathan Kayarohanam
1,
Vetriselvan Subramaniyan
2,
Ashok Kumar Janakiraman
3,
S. J. Madhan Kumar
3
Affiliations
1 Geomatika University College Kuala Lumpur, 54200, MY
2 Department of Pharmacology, MAHSA University, 42610, MY
3 UCSI University, Kuala Lumpur, 56000, MY
1 Geomatika University College Kuala Lumpur, 54200, MY
2 Department of Pharmacology, MAHSA University, 42610, MY
3 UCSI University, Kuala Lumpur, 56000, MY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3511-3516Abstract
Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods and Material: Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia. Statistical analysis : Data were analysed by One - way ANOVA, followed by Turkey –Kramer Multiple Comparison Test. Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.Keywords
Dolichandrone atrovirens, Streptozotocin, in Vivo Activity, Antidiabetic.
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