Research Journal of Pharmacy and Technology

Minakshi Shroff ¹, S. J. Daharwal ², Yashwant Swarnakar ³

Affiliations
1 Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun, GB
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
3 Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai (C.G.), IN

Abstract

In the present work, ten novel 3-(4,5-dihydro-3-(naphthalen-1-yl)- N1-substituted -pyrazol-5-yl)-1H-indole [1,1a,1b.1e,2] and 3-(4,5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5,5a,5b,5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenaninduced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.

Keywords

Anti-Inflammatory Activity, Carageenan Induced Paw Oedema Method, Indole, Pyrazoline, Indolyl Pyrazoline.

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Seema Singh ¹, Rajendra Jangde ¹, S. J. Daharwal ¹

Affiliations
1 University Department of Pharmacy, Pt. Ravishankar Shukla University Raipur, Chhattisgarh, (492010), IN

Abstract

The herbal drugs have natural active compound, nutrients they may be helpful to care and treatment of wound and other human health. The number of herbal plants has been used for the treatment and management of wound over the year. Wound healing is a process of restoring normal cellular structure, function of damaged tissue. Healing is a natural phenomenon; in which the body overcome the damaged surface or tissue and they may recover the damaged part of living tissue, but this phenomena healing rate of wound is very slow and many chance of infection in wound by microbes and its several risks to body. Hence to improve the healing phenomenon and shorter the duration of recovery of the damaged tissue. In India there are many plants used traditionally to cure the wound and the human health. The present review highlights some herbal and medicinal plant with their active compound, which are scientifically used to treatment of cut, burn, or wound as a healer.

Keywords

Bioactive, Wound Healing, Herbal Treatment.

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