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Fernandes, Ronald
- Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn
Abstract Views :163 |
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Authors
Sonal D’Souza
1,
Jennifer Fernandes
1,
M. Vijay Kumar
1,
Nishmitha Gretta D’Souza
1,
Ronald Fernandes
1
Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 241-244Abstract
The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.Keywords
Annona Reticulata, Antiepileptic Activity, MES, PTZ.
References
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- Jhamkhande PS, Wattamwar AS, Chandak PG.The invitro anthelmintic efficacy of ethno-medicinal plant Annona reticulata ischolar_mains against Indian earthworms. IJNPR. 2014; 5(2):152-157.
- Thang TD, Kuo PC, Huang GJ, Hung NH, Huang BS, Yang ML et al. Chemical constituents from the leaves of Annonareticulata and their inhibitory effects on NO production. Molecules. 2013;18:4477-4486.
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- In Vitro Antioxidant Activity of Leaves Extracts of Areca catechu
Abstract Views :290 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1536-1540Abstract
Areca catechu L. (Arecaceae) is a species of palm mainly grown in Asian countries for seed crop. Areca nut leaves are commonly used in traditional systems of medicine against various ailments. There is a need for identifying native natural plant sources to acquire their recognized medicinal properties, which may widen them to use as new therapeutics for various diseases. The present work was aimed to evaluate the in vitro pharmacological screening of the extracts of the leaves of Areca catechu L. by DPPH assay, nitric oxide radical scavenging activity, hydrogen peroxide radical scavenging activity and total antioxidant capacity. The extracts of the leaves of Areca catechu L. showed significant results with the standard ascorbic acid.Keywords
Antioxidant Activity, DPPH, Areca catechu, Nitric Oxide Radical Scavenging Activity, Ascorbic Acid.References
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- Yildrim A, Oktay M, Bilaloglu V. The antioxidant activity of the leaves of Cydonia vulgaris. Turkish J. Med. Sc. 2001:31, 23-27
- Jaiswal P, Kumar P, Singh VK, Singh DK. Areca catechu L.: A valuable herbal medicine against different health problems. Research Journal of Medicinal Plants. 2011;5(2):145-152.
- Joseph BS, Kumbhare PH, Kale MC. Preliminary phytochemical screening of selected medicinal plants. Int Res J Sci Eng. 2013;1(2):55-62.
- Nagmoti DM, Khatri DK, Juvekar PR, Juvekar AR. Antioxidant activity and free radical scavenging potential of Pithecello mbiumdulce Benth seed extracts. Free Radical and Antioxidants. 2011;2(2):37-43.
- Md. Alam N, Bristi NJ, Md. Rafiquzzaman. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharmaceutical Journal. 2013;21:143-152.
- Ebrahimzadeh MA, Nabvi SM, Nabvi SF, Bahramian F, Bekhradnia AR. Antioxidant and free radical scavenging activity of H. officinalis L. var. Angustifolius, V. odorata, B. hyrcanaand C. speciosum. Pakistan Journal of Pharmaceutical Sciences. 2010;23(1):29-34.
- Priyanka B, Anitha K, Shirisha K, Janipasha SK, Dipankar B et al. Evaluation of antioxidant activity of ethanolic ischolar_main extract of Albizialebbeck (L.) Benth. IRJPAS. 2013;3(2):93-101.
- Thakur S, Chilikuri P, Pulugurtha B. Screening of in vitro antioxidant and anti-inflammatory activity of methanolic extract of Oxalis corniculata Linn. IJPPS. 2010;2(1):146-155.
- In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus
Abstract Views :389 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, IN
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3265-3267Abstract
Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.Keywords
in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.References
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- Taksim Ahmed, Mohammad Nasir Uddin, Shaikh Faisol Ahmed, Arindam saha, Kaniz Farhana, Md.Sohel Rana. Invitro evaluation of antioxidant potential of Artocarpus charma Buch. fruits. Journal of Applied Pharmaceutical Sciences 2012, 2(10): 75-80.
- Hashim NM, Mawardi Rahmani, Cheng LE, Sukari MA, Maizatulakmal Yahayu, Muhamad AMA, Ali AM, Rusea G. Antioxidant, Antimicrobial and tyrosinase inhibitory Activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett: Molecules. 2012, 17, 6071-6082.
- Unnikrishnan PS, Suthindhiran K, Jayasri M. Alpha-amylase inhibition and antioxidant activity of marine green algae and its possible role in diabetes management. Pharmacog. Mag. 2015 Oct, 11(4): S511-S515.
- Madhusudhan Telagari and Kiran Kumar Hullatti. In vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. Extracts and fractions. Indian Journal of Pharmacology. 2015 Jul-Aug, 47(4):425-429.