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Narayana Charyulu, R.
- Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent
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Authors
Affiliations
1 Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, IN
2 Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, IN
1 Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, IN
2 Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 747-750Abstract
In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.Keywords
Omeprazole, Orodispersible Tablets, Superdisintegrants.- Formulation and Evaluation Ungual Drug Delivery System of Antifungal Agent for Nail Disorders
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Authors
R. Narayana Charyulu
1,
D. S. Sandeep
1,
Abhishiktha Alva
1,
Divya Rao
1,
Prashant Nayak
1,
Jobin Jose
1,
K. C. Bahrath Raj
2
Affiliations
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 869-872Abstract
Fungal infections affecting nails are commonly seen around the world. The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). The current research aims at ungual drug delivery system as an effective treatment in nail infections. The formulations of nail lacquer were made with Amorolfine as antifungal agent using different concentration of polymer Eudragit RL 100 (ERL 100). Among 6 formulations, formulation F5 and F6 showed very good physical characteristics like viscosity, water resistance, stability, drying time, smoothness as compared to other formulations. The zone of inhibition of antifungal activity showed desired results (F5 and F6).Keywords
Nail Lacquer, Polymer, Ungual Drug Delivary, Viscosity.- Design and Evaluation of Bigels Containing Flurbiprofen
Abstract Views :265 |
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Authors
Affiliations
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, IN
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 143-152Abstract
The present study was aimed of design and evaluation of bigel containing flurbiprofen. Bigels are interesting innovative two phase systems that have been recently proposed as structured system for delivery of active ingredients. They possess the advantages of both hydrogel and organogel. Organogel was prepared by pluronic lecithin and hydrogel was prepared using HPMC. Bigels were prepared by mixing of organogel and hydrogel in appropriate ratio. Organogel and hydrogel was evaluated for pH, viscosity, extrudability and spreadabilty. Formulation F3 from organogel and formulation H3 from hydrogel was selected as optimized formulations and was used for the preparation of bigel. The prepared bigel was evaluated for pH, viscosity, extrudability, spread ability, in vitro drug release studies, ex vivo permeation studies, stability studies and skin irritation test. All formulations of bigel showed extended release out of which formulation B3 was selected as the optimized formulation on the basis of evaluation parameters. In vitro permeation release was found to be 89.99% at the end of 8 hrs. The release kinetics of flurbiprofen bigel followed Higuchi model. The bigels were found to be stable and skin irritation studies on Wistar rats showed that the prepared bigels were compatible. Based on the encouraging results bigels containing flurbiprofen can be used as extended release system.Keywords
Flurbiprofen, Organogel, Hydrogel, Bigel, HPMC.References
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- Oral Dispersible Films, Novel Technology for the Delivery of Drugs
Abstract Views :232 |
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Authors
Affiliations
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 425-428Abstract
Various dosage forms have been introduced in the recent days in the field of pharmaceutical technology. Transdermal patch is a technique from which a new drug delivery system that is oral dispersible film was developed. Oral dispersible films when they placed on mouth or oral cavity, they disintegrate or dissolve within a minute. Even though in a solid dosage form it doesn’t require chewing or drinking of water, which enhances the patient compliance. There are number of ingredients are used to formulate oral dispersible patches, like active pharmaceutical ingredients, polymers, flavouring agents, colouring agents etc, in which we can regard polymer as important ingredient which helps to form the film. Usually hydrophobic polymer are used for oral dissolving films which breaks down on the tongue or buccal cavity and then drug will go to systemic circulation. Fast disintegrating property, good mechanical property like mouth dissolving property of film can be achieved by water soluble polymer. Moreover in oral dispersible films, accurate and effective dosing can be accomplished in a safe manner.Keywords
Oral Dispersible Films, Hydrophilic Polymers, Plasticizers, Solvent Casting.References
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