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Chacko, Nimmy
- Ameliorative Potential of Eclipta albaon Gentamycin Induced Renal Toxicity in Rats
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Authors
Prince Thomas
1,
M. P. Gururaja
1,
Himanshu Joshi
1,
K. Prasannashama
1,
Ullas D’Souza
1,
Nimmy Chacko
1,
K. C. Bharath Raj
1,
K. S. Rajesh
1
Affiliations
1 NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, IN
1 NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 192-196Abstract
Nephrotoxicity is a common event, which can cause significant morbidity and can be easily overlooked. Gentamycin is an antimicrobial agent which can cause nephrotoxicity on prolonged use. A large number of herbs have traditionally been used to treat drug or toxin-induced renal diseases. The present study was a similar attempt in that direction to evaluate the nephroprotective activity of ethanolic extract of whole plant of Eclipta alba against gentamycin induced nephrotoxicity. The animals were divided into five groups (n=6) consisting of normal control, toxic control and three test groups which received different doses of the extract (100,200 & 400mg/kg, p.o). Nephroprotective effect of ethanolic extract of Eclipta alba was evaluated by assessing the blood parameters and histopathological studies of kidney. Elevated levels of serum urea, serum creatinine, total protein and uric acid have been significantly reduced in dose depending manner by oral administration of ethanolic extract of whole plant of Eclipta alba. These observations were supported by histopathological studies.Keywords
Eclipta alba, Gentamycin, Nephrotoxicity, Nephroprotection.
References
- Iqbal H, Naeem K, Riaz U, Shanzeb, Shabir A, Farhat AK., et al. Phytochemical, physiochemical and anti-fungal activity of Eclipta alba. Afr. J. Pharm. Pharmacol 2011;5(19):2150-5.
- NazimUddin, AtiarRahman, SohelRana, RashedaAkter, Masudul Azad Chowdhury. Antioxidant, cytotoxic and antimicrobial properties of Eclipta alba ethanol extract. Int J Biol Med Res 2010;1(4):341–6.
- New OCED 425 guidelines. OCED Guidelines for testing animals.2001 Dec 1; 26: 1-26.
- Turner RA. Screening methods in pharmacology. New York: Academic press INC; 1965.
- Kaplan A, Lavernal LS. Clinical Chemistry: Interpretation and techniques. 2nd ed. Philadelphia: Lea and Febiger; 1983.
- Murray RL. Non protein Nitrogen Compounds. In: Kaplan LA, Pesce AJ, Eds. Clinical Chemistry: Theory, Analysis and Corelation. Toranto:Mosby; 1984.p. 1230-68.
- Koller A .Proteins. In: Kaplan LA, PesceAJ, editors. Clinical Chemistry:Theory, Analysis and Co-relation. Toranto:Mosby; 1984.p.1268-1327.
- Wootton IDP. Micro-analysis in Medical Biochemistry.4th ed. London: Churchil Livingstone;1964. p.86.
- Sudhavani V, Chinnikrishnaiah V, Raghu MV, Raghavendra HG, Ranganayakulu D. Nephroprotective activity of Merremiaemarginataburm against cisplatin induced nephrotoxic rats. Journal of Advances in Drug Research 2010; 1( 1):27-34.
- LakshmiB V S, Sudhakar M. Protective effect of Zingiber officinale on gentamycin induced nephrotoxicity in rats. Int. J. Pharmacol 2010;1:1-5.
- Devipriya S, Shyamaladevim CS. Protective effect of quercetin in cisplatininduced cell injury in the rat kidney. Indian J. Pharmacol 1999; 31: 422.