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Damodharan, N.

Isolation and Screening the Pharmacological Activities of Vegetative and Spore-Crystal Proteins from Bacillus thuringiensis

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Authors

R. Kavitha ¹, N. Damodharan ¹, S. Sangeetha ¹, P. N. Remya ¹, T. S. Saraswathi ¹

Affiliations
1 Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Kattankulathur, Tamil Nadu, IN

Source

Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 38-40

Abstract

Bacillus thuringiensis, the most successful and most widely used microbial insecticide, produces crystal proteins. The physiological significance of the crystal proteins poorly understood except for the potent insecticidal activity. In the current study, an attempt made to isolate vegetative and spore-crystal proteins from Bacillus thuringiensis NCIM2514 and to perform their hemolytic and antioxidant activities. The proteins were separated by salting out methods then by using SDS-PAGE. The molecular protein weight of the vegetative and spore-crystal protein identified as the presence of low molecular weight protein. Pharmacological activities as antioxidant and hemolytic studies were performed for the crude proteins and found as Spore-crystal proteins contain more anti-oxidant when compared to vegetative proteins.

Keywords

Bacillus thuringiensis (Bt), Spore-Crystal Proteins, Vegetative Proteins. SDS-PAGE, Antioxidant.

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References

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pH-Responsive Polymers and its Application in Drug Delivery System and Pharmaceutical Field

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Authors

Nilmani Prasad Gupta ¹, N. Damodharan ²

Affiliations
1 Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai –603202, IN
2 Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai – 603202, IN

Source

Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 944-958

Abstract

Stimuli-sensitive polymers which are also called as ‘smart polymers' are rapidly acquiring popularity in the field of self-regulated and control release drug delivery system. Control drug delivery system is used which enable to obtain better drug product with greater safety, efficacy, and reliability. Stimuli-responsive polymers (smart polymers) are the large molecules which in response to environmental factor like, light, heat, ionic and magnetic field reveals peculiar physiochemical changes. The review summarizes the recent development explaining different types of synthesis, its characteristics, the principle of working, and its application in various fields. Several polymers with its potential uses in control drug delivery, personal, human care, biological and membrane science as well as its application in the pharmaceutical field are explained below. They have been playing a vital role in various fields since last three decades. In the field of chemistry and biology, pH-sensitive materials having multi-characteristics nature makes a promising role. It also describes about an important use of pH-sensitive polymer in different therapy like gene therapy and the applicability of system as insulin delivery in consideration of physiochemical properties of these smart polymers. Apart of drug delivery, It has also an important application in purification and separation of molecules like enzyme, protein, peptides (Chromatographic studies).

Keywords

pH-Sensitive Polymer, Liposomes, Drug Delivery, Polymethacrylic Acid, Poly (Acrylic Acid).

Full Text

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Floating Osmotic Drug Delivery System:A Review

Abstract Views :147 | PDF Views:0

Authors

Bharadhwaj Ramesh Iyer ¹, N. Damodharan ²

Affiliations
1 SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, IN
2 Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, IN

Source

Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 959-971

Abstract

Floating Osmotic Drug Delivery System (FODDS) is a controlled oral drug delivery system which comes under the category of Gastroretentive Drug Delivery (GRDDS). It is based upon the osmotically controlled release mechanism which offers a sustained therapeutic action while reducing the side effects. Various drugs with a shorter half-life and a small absorption window get highly benefited By FODDS. FODDS also finds a unique place among the other GRDDS by surpassing their performance. FODDS incorporates a variety of ingredients such as osmotic agents, semi permeable substance, gas generating Agent and a gel forming agent. The preparation of the system involves techniques like direct compression and coating process. Characterisation studies like in-vitro dissolution study, in-vivo radiological study and pharmacokinetic study were adapted for evaluation of FODDS. Many studies have been carried out to illustrate the efficiency of the FODDS in overcoming the drawbacks such as poor bioavailability, drug wastage etc. Active agents derived from the field of pharmacognosy have also been benefited by FODDS since they prevent the enzymatic degradation of the active agents and and improve their bioavailability. FODDS also provides a robust pharmacokinetic profile with both in-vitro and in-vivo drug release rate which results in excellent in-vitro/in-vivo correlation due to its controlled release mechanism. This review is primarily focused on providing an overall insight into FODDS while giving detailed information regarding its design, development, mechanism, characterisation and a precise overview of various studies carried out using FODDS.

Keywords

Drug Delivery System, Intragastric System, Gastro Retentive, Floating Osmotic System, Controlled Drug Delivery.

Full Text

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