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Mitra, Mitashree
- Haplotype and Allelic Variations at Dopamine Receptor Gene (DRD2) among Six Austro-Asiatic Speaking Tribal Groups of Central India
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1 Department of Forensic Science, Guru Ghasidas University, Bilaspur (C.G), IN
2 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G), IN
1 Department of Forensic Science, Guru Ghasidas University, Bilaspur (C.G), IN
2 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G), IN
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Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 54-60Abstract
Central India is mainly constituted by two states, namely; Madhya Pradesh and Chhattisgarh that are homeland of several caste and tribal groups speaking diverse language belongs to Indo-European, Dravidian and Austro-Asiatic thus makes it an important place for testing several language-gene interaction models. Various archaeological evidences indicated that the Narmada region has played a significant role in initial peopling of the Asian subcontinent. There is a necessity to fill the big lacuna by inclusion of this region to reveal a continuous picture of the origin and genetic affinity of the Indian population. It is hypothesized that Austro-Asiatic speaking tribes are autochthonous to India. The present study was conducted to examine the haplotype variations at Dopamine Receptor Gene (DRD2) in the Austro-Asiatic Speaking Tribal Groups of Central India. Haplotypes provide information on evolutionary histories, beyond what can be learned from individual marker. A total of 327 unrelated samples belonging to Birhor, Gadaba, Kol, Hill korwa, Saora and Baiga were analyzed for three selected TaqI sites of DRD2 gene using Polymerase chain reaction (PCR). All the loci were found to be polymorphic among the studied populations. The frequency of ancestral allele B2 is less than 50% in all six populations (41.4-49.2%) while D2 allele exhibit frequency of 15.3-44.8%. A1 allele observed with a frequency ranging from 36.2-48.2%. The average heterozygosity ranged from 0.417 in Baiga to 0.501 in Kol. The ancestral haplotype (B2D2A1) in all six populations exhibit 0% frequency. LD values calculated for the three bi-allelic sites, TaqIB, TaqID, and TaqIA are low, i.e., below 0.8 with respect to all populations in each pair. Overall, allele frequency distribution patterns and high average heterozygosity values, suggest a genetic proximity among the studied populations. Low recurrence of genealogical alleles and nonattendance of familial haplotype in the examined populace bunches, demonstrating towards indigenous inception of Central Indian Austro-Asiatic talking tribes.Keywords
Austro-Asiatic, DRD2, Haplotype, PVTG, Polymorphic, Central India.
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- Attitude Towards Impotence And Barren among the Baiga Males of Chhattisgarh, India
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Authors
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1 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G), IN
1 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G), IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 41-47Abstract
Several conceptions and misconceptions prevail in human society about sexual impotency. In different human societies in different human cultures, opinions and criteria regarding impotence vary. Such opinions and criteria become perceptions in that particular society. Such perceptions were also traced in the Baiga community, which are presented in this paper. Objectives of the study are to explore notions about impotence and barren among the Baiga males of Chhattisgarh, India. The universe of our sample is 400 married Baiga males belonging to age 18-49 years. The Baiga tribe is one of seven Particularly Vulnerable Tribal Group (PVTG) of Chhattisgarh state of India. In the present study multi-stage random sampling method were followed. Structured interview schedules, focused group discussions and non-participant observation were used for collection and cross validation of data. According to the findings 33.5% respondents regard those males impotent who in the course of his youthful age could not make his wife pregnant. 30% respondents have the conviction that witchcraft and sorcery are the main causes of suffering from impotency. Perception regarding impotence among the Baiga males is found to be very placid and positive influenced by their age with value of χ2 = 1.153 and value of p is 0.020 at 5% level of significance. More than of half of them (50.8%) agreed that if any woman was unable to conceive, she was castigated as “barren”. Perception about barrenness among the Baiga males is found to be moderate and positively depended on their educational status, with associated value of χ2 = 30.32 and value of p is 0.016 at 5% level of significance. From the observation of multi-nomial logistic regression test, the finding was: in order to, all the above causes were found responsible for the barrenness of any women, which were relative to result as deities, breach of taboos and magic and witchcraft held responsible for barrenness at value of β for predictor's age at marriage of the respondents, i.e., < 18 years had been found to be -1.069 with associated value of p is 0.048 at 5% level of significance. From the extant study one thing that came to light was that those men who are younger in age hold such forces less responsible than their elderly counterparts who happen to be more credulous, even superstitions. The fact also emerged through the study that with the rise in educational status and income, the general attitude of the male Baiga towards barrenness of women have become realistic and scientific.Keywords
Attitude. Impotence. Barren. The Baiga. Tribe. Chhattisgarh. India, Reproductive Health.References
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- Association of TNF-308 Gene Polymorphism with Cervix Cancer Susceptibility among Women of Chhattisgarh
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Authors
Affiliations
1 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
2 Department of Gynaecology, Dr. B.R. Ambedkar Memorial Hospital, Raipur (C.G.), IN
1 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
2 Department of Gynaecology, Dr. B.R. Ambedkar Memorial Hospital, Raipur (C.G.), IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2339-2342Abstract
Tumour Necrosis Factor (TNF), being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumourigenesis. TNF has been shown to mediate carcinogenesis through induction of proliferation, invasion, and metastasis of tumour cells. Polymorphisms within TNF genes can result in pathogenesis and promoting malignant progression of cervix cancer. In the present hospital based case-control study, 230 cervix cancer patients (cases) and 230 controls were studied to determine the association of TNF-308 gene polymorphism with cervical cancer. TNF-308 null genotype showed significance distribution among cases and control (χ2=18.759, df =2, p = 0.00008). Women carrying the heterozygous A allele had a two-fold increased risk of developing cervix cancer (OR=1.775; 95% CI [1.178-2.674]) while the risk of cervix cancer raises to three-fold when A allele is preset in homozygous condition (OR=3.186; 95% CI [1.775-5.719]). These findings indicate that TNF-308 polymorphisms play crucial role in the development of cervix cancer.Keywords
Cervix Cancer (CC), Case-Control Study, TNF-308 Gene Polymorphism, Homozygous and Heterozygous Alleles, Chhattisgarh.References
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