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Taha, Mariam Mahmoud
- Evaluation of the Effectiveness of Antioxidants and TNF-α in Iraqi Patients with Psoriasis Reated with Etanercept
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1 Department of Biology/College of Education for Pure Science- Ibn- Al-Haitham/University of Baghdad, IQ
1 Department of Biology/College of Education for Pure Science- Ibn- Al-Haitham/University of Baghdad, IQ
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 665-668Abstract
Psoriasis was initially considered one of the disorders of keratinocytes. At present it has been classified as one of the autoimmune diseases mediated by T cells, The aim of this study was to identify the effect of biologic therapy on the factors responsible for oxidative stress and lipid oxidation and compare it with TNF-α in a sample of patients with psoriasis and treated with Etanercept. The study sample consisted of 137 people, 48 patients treated with Etanercept, 50 people representing the healthy group (control), 20 patients treated with MTX and 19 treated with topical treatment. The results of the present study showed a significant decrease in the level of motor TNF-α in serum group of patients with psoriasis and treated with biological therapy (33.66 ± 3.41)There was also a non significant increase in the effectiveness of the CAT enzyme between the control group and the biological treatment group as it was effective in the serum of patients treated with biological treatment (6.42 ± 0.44). The results of the measurement of the level of Glutathion enzyme in the serum there is a significant increase between the treatment groups and control group, Significant decrease in MDA concentration between the treatment groups compared to the control group. We conclude that the height of both GSH concentration, CAT efficacy and low MDA concentration indicates a decrease in lipid oxidation process, reduced oxidative stress and reduced disease progression and severity after treatment with etanercept psoriasis.Keywords
Antioxidants, TNF-α, Psoriasis, Etanercept.
References
- Boyman O., Hefti H. P., Conrad C., Nickoloff B. J., Suter M., Nestle F. O. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α. J. Exper. Med., 2004, 199(5), 731-736.
- Gottlieb A. B. Psoriasis. Immunopathology and immunomodulation. DermatolClin. 2001, 19:649-657.
- Ferenczi K., Burack L., Pope M., Krueger J. G., Austin L. M. CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J. Autoimmun., 2000, 14(1): 63-78.
- Kim J., Krueger J. G. The immunopathogenesis of psoriasis. Dermatologic Clinics, 2015, 33(1), 13-23.
- Ivanova IP, Mareeva TE. Disorders of lipid peroxidation and oflysosomal hydrolase activity and their correction in psoriasis patients.VestnDermatolVenereol 1987, 4: 26-31.
- Elango T., Thirupathi A., Subramanian S., Ethiraj P., Dayalan H., Gnanaraj P. Methotrexate treatment provokes apoptosis of proliferating keratinocyte in psoriasis patients. Clin. Exper. Med., 2017, 17(3), 371-381.
- Mahiques L., Pitarch G., Sánchez-Carazo J. L., Pérez-Ferriols A., Soriano C. J., Alegre V. Analysis of Lymphocyte Populations in Psoriatic Plaques Following Inhibition of Tumor Necrosis Factor-α With Etanercept. ActasDermo-Sifiliográficas (English Edition), 2007, 98(8), 539-544.
- Chua R. A.,Arbiser J. L., Chua R. A., Arbiser J. L. The role of angiogenesis in the pathogenesis of psoriasis. Autoimmunity, 2009, 42(7), 574-579.
- Conrad, C., &Gilliet, M. Psoriasis: From pathogenesis to targeted therapies. Clin. Rev. Allergy Immunol., 2018, 54(1): 102-113.
- Hay F.C. Westwood O. M. Practical Immunology. 4thed. Black- well Science. USA.409, 2002.
- Aebi, H. Catalase in vitro. In Methods Enzymol., 1984, 105, 121-126.
- Tietz N. W. Textbook of clinical chemistey, 3rd ED C. A. Burtis, ER Ash wood, W. B. Saunders. Pp:826-835, 1999.
- CeconiC., Cargnoni A., Pasini E., Condorelli E., Curello S., Ferrari R. Evaluation of phospholipid peroxidation as malondialdehyde during myocardial ischemia and reperfusion injury. Amer. J. Physiology-Heart Circulatory Physiol., 1991, 260(4), H1057-H1061.
- Newland M. R., Weinstein A.,KerdelF. Rapid response to infliximab in severe pustular psoriasis, von Zumbusch type. Int.J. Dermatol., 2002, 41(7), 449-452.
- Scallon B. J., Moore M. A., Trinh H., Knight D. M., Ghrayeb J. Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions. Cytokine, 1995, 7(3), 251-259.
- Kalf H. Y. Study of some immunological aspect in patients with psoriasis in some Baghdad hospitals. B.SC. Biology. The collage of women university of Baghdad.(Abstract), 2015.
- Baz K., Cimen M. Y., Kokturk A., Yazici A. C., Eskandari G., Ikizoglu G., Atik U. Oxidant/antioxidant status in patients with psoriasis. Yonsei Medical Journal, 2003, 44(6), 987-990.
- Kural B. V., Örem A., Çimşit G., Yandı Y. E., Calapoǧlu M. Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant–antioxidant system in patients with psoriasis. ClinicaChimicaActa, 2003, 328(1-2), 71-82.
- Peluso I., Cavaliere A., Palmery M. Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis. Journal of biomedical science, 2016, 23(1), 52.
- Houshang N, Reza K, Masoud S, Ali E, Mansour R, Vaisi-Raygani A. Antioxidant status in patients with psoriasis. Cell Biochemistry and Function. 2014, 32:268–273.
- Seifert O., Holmberg J., Linnarsson B. M. Decreased activity of neutrophil glutathione peroxidase in chronic plaque-type psoriasis. Journal of the American Academy of Dermatology, 2007, 57(3), 528-529.
- Rocha‐Pereira P., Santos‐Silva A., Rebelo I., Figneiredo A., Quintanilha A., Teixeira F. Erythrocyte damage in mild and severe psoriasis. British Journal of Dermatology, 2004, 150(2), 232-244.
- Hamzah I. M. Oxidative stress markers (MDA,SOD&GSH) and Proinflammatory Cytokine (interleukine-18)in Iraqi patients with Psoriasis vulgaris. Kerbala J. Med., 2014, 7, 1912-1918.
- Al-Tammimy, S. M., Al-Rubayee, W. T., &Alwasiti, E. A.Serum copper, zinc and oxidative stress in patients with psoriasis. Iraqi J. Med. Sci., 2011, 9(2), 137-142.