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Lakshmi, K. S.
- Spectrophotometric Quantification of Telmisartan Employing Multivariate Calibration Technique in Bulk and Pharmaceutical Formulations
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, IN
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1799-1805Abstract
The present study focuses on the development and validation of an accurate, precise, sensitive and rapid multivariate calibration technique employing UV spectrophotometric method for the quantification of Telmisartan in bulk and pharmaceutical formulation. Multivariate calibration technique utilises the linear regression equations by correlating the relation between concentration and absorbance at five different wavelengths thereby improves the correlation and minimises the instrumental fluctuations. Telmisartan shows absorption maximum at 296 nm in alkaline condition, and good linearity was obtained in the range of 5 - 15 μg/mL. The other parameters were validated and were found to be following ICH guidelines.Keywords
Telmisartan, Antihypertensive, UV Spectrophotometer, Multivariate Calibration, ICH Guidelines.
References
- Tripathi KD. Essentials of Medical Pharmacology - 7th ed, 507.
- The Merck Index, 14th ed, USA: Merck and CO., Inc., 2006: 1569.
- The Indian Pharmacopoeia, 8th ed, The Indian Pharmacopoeia Commission, Ghaziabad, vol. III, 2018: 3320-3321.
- The United states Pharmacopoeia. The national formulary. Rockville, MD: The United States Pharmacopeial Convention, Inc., vol. II, 2018: 3957-3959.
- The British Pharmacopoeia, 6th ed, Stationery office on behalf of the Medicines and Health care Products Regulatory Agency (MHRA), vol.II, 2011: 2085.
- Chavda JM, Raval MA, Dave KR. Simultaneous estimation of Telmisartan and Indapamide in Bulk Drug and in Pharmaceutical dosage form using UV-Spectrophotometry. Asian Journal of Research in Chemistry. 5(9); 2012: 1129-1135.
- Thote LT, Umarkar AR, Chaple DR. Development of UV Spectrophotometric Methods for Simultaneous Estimation of Atorvastatin and Telmisartan in Combined Dosage Form Using Simultaneous Equation Method. Asian Journal of Research in Chemistry. 4(11); 2011: 1777-1779.
- Mukesh K. Nagar, Dhabale PN, Hosmani AH. Validated Spectroscopic Method for Estimation of Telmisartan from Tablet Formulation. Asian Journal of Research in Chemistry. 4(11); 2011: 1664-1665.
- Shishir Maheshwari, Preeti Tiwari, Atul srivastav. Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form. Asian Journal of Research in Chemistry. 6(8); 2013: 765-768.
- Shishir Maheshwari, Atul Srivastav. Development and Validation of Multi-Component Mode UV Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form. Asian Journal of Research in Chemistry. 6(10); 2013: 973-976.
- Zonghui Qin, Weifen Niu, Rong Tan. Spectrophotometric method for the determination of Telmisartan with Congo Red. Journal of Analytical Chemistry. 64; 2009: 449-454.
- Sunil Singh, Ajit Kumar Yadav, Hemendra Gautam. First order Derivative Spectrophotometric Determination of Telmisartan in Pharmaceutical Formulation. Bulletin of Pharmaceutical Research. 2(2); 2012: 83-86.
- Pratap Y. Pawar, Manish A. Raskar, Swati U. Kalure, Reshma B. Kulkarni. Simultaneous spectrophotometric estimation of Amlodipine besylate and Telmisartan in tablet dosage form. Der Pharma Chemica. 4(2); 2012: 725-730.
- Krishanu Pal, Bhagavan Raju M, Pavan Kumar K, Rahul Chakravorthy. Simultaneous Determination of Telmisartan and Ramipril in Tablet Dosage Form by Spectrophotometry. Research Journal of Pharmacy and Technology. 3 (3); 2010: 861-864.
- Delhiraj N, CH Narisimaraju BH, Anbazhagan S. Simultaneous spectrophotometric estimation of Telmisartan, Amlodipine besylate and hydrochlorthiazide in pharmaceutical dosage form. International Journal of Chemical and Pharmaceutical Sciences. 3(3); 2012: 33- 36.
- Niranjan D. Chivate, Siddharth M. Patil, Jagdish K. Saboji, Anuradha N. Chivate. Development of UV Spectrophotometric method for estimation and validation of Telmisartan as a pure API. Journal of Pharmacy Research. 5(6); 2012: 3331-3333.
- Kranthi Kumar Y, Ravipratap Pulla, Vanitha Prakash K, Kranti Sri Mulpuri. New Extractive Spectrophotometric Method for the determination of Telmisartan. Indo American Journal of Pharmaceutical Research. 3(12); 2013: 1509-1512.
- Venkatesan Subramanian, Kannappan Nagappan Analytical method development and validation of Telmisartan and Hydrochlorthiazide in tablets using Orthogonal polynomial function method. International Journal of Pharmacy and Pharmaceutical Sciences. 5(1); 2013: 73-75.
- Bhargav K. Solanki, Dave JB, Priyanka P. Raval. Development and validation UV Spectrophotometric methods for simultaneous estimation of Rosuvastatin and Telmisartan in tablet dosage form. World Journal of Pharmacy and Pharmceutical Sciences. 3(6); 2014: 2030- 2041.
- Aya I. Badran, Hamed M.EL-Fatatry, Shrein F. Hammad. Simultaneous estimation of Telmisartan and amlodipine by Second derivative Spectrophotometric Method and First Derivative Ratio- Spectrophotometric Method. American Journal of Pharm Tech Research. 5(2); 2015: 170-189.
- Gupta NK, Peepliwal A, Rathore DS, Gupta P. Simultaneous Spectrophotometric estimation of Telmisartan and Amlodipine besylate in tablet dosage form. Indian Journal of Pharmaceutical and Biological Research. 3(3); 2015: 50-54.
- Santosh Kumar Vobbilireddi, Sujana K, Prameela Rani A. New Validated UV- Spectrophotometric Method for the Determination of Telmisartan in Bulk and Dosage Form. Research Journal of Pharmacy and Technology. 5(9); 2012: 1209-1212.
- Yeole MP, Asnani AJ. Simultaneous Determination of Telmisartan and Amlodipine in Tablets by Reverse Phase High Performance Liquid Chromatography. Research Journal of Pharmacy and Technology. 4 (1); 2011: 75-77.
- Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja. RP-HPLC Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril in pure and Pharmaceutical Dosage forms. Asian Journal of Research in Chemistry. 10(2); 2017:179-185.
- Kamalakannan D, Vijay Amirtharaj R, Senthilkumar N. Simultaneous Estimation of Telmisartan and Pioglitazone in Pharmaceutical Dosage Form by RP-HPLC Method. Asian Journal of Research in Chemistry. 3(2); 2010: 364-366.
- Kalai Selvi P, Venkatachalam T, Kishor Kumar V, Lalitha KG. RP-HPLC Method for Simultaneous Determination of Pioglitazone and Telmisartan in Tablet Dosage Form. Asian Journal of Research in Chemistry. 3(3); 2010: 585-587.
- Shen J, Jiao Z, Li ZD, Shi XJ, Zhong MK. HPLC determination of Telmisartan in human plasma and its application to a Pharmacokinetic study. Pharmazie. 60; 2004: 418-420.
- Vekariya NR, Patel GF, Rohit B Dholakiya. Determination of Telmisartan in Solid Dosage Form by RP-HPLC. Asian Journal of Research in Chemistry. 2(4); 2009: 506-508.
- Ridhdhi S Sinojiya, Vasant Khasia, Bhaven J Patel, Amish A Dangi. Development and Validation of RP-HPLC Method for the Simultaneous Determination of Telmisartan, Amlodipine Besylate and Hydrochlorothiazide in a Tablet Dosage Form. Journal of Pharmacy Research. 5(8); 2012: 4154 - 4157.
- Hassan A. Alhazmi, Ahmed M. Alnami, Mohammed A. A. Arishi, Raad K. Alameer, Mohammed Al Bratty, Zia ur Rehman, Sadique A. Javed, Ismail A. Arbab. A Fast and validated Reversed-Phase HPLC Method for simultaneous determination of Simvastatin, Atorvastatin, Telmisartan and Irbesartan in bulk drugs and tablet formulations. Scientia Pharmceutica. 86(1); 2017: 1 - 13.
- Chabukswar AR, Jagdale SC, Kumbhar SV, Desai DJ, Kuchekar BS, Lokhande PD. HPLC Method Development for Telmisartan and Amlodipine. Research Journal of Pharmacy and Technology. 3 (4); 2010: 1227-1230.
- Vijay Kumar G, Murthy TEGK, Sambasiva Rao KRS. Validated RP-HPLC Method for the estimation of Telmisartan in serum samples. International Journal of Research in Pharmacy and Chemistry. 1(3); 2011: 703 - 706.
- Bhavna A. Patel, Anandkumari D. Captain. RP-HPLC Method for simultaneous estimation of Telmisartan and Hydrochlorthiazide in API and dosage form. Indo American Journal of Pharmceutical Research. 4(06); 2014: 3031 - 3038.
- Shaik Maimoon, K. Narendra Kumar Reddy, P. Swetha. RP-HPLC method development and validation for simultaneous estimation of Amlodipine besylate and Telmisartan in tablet dosage form. Indian Journal of Research in Pharmcy and Biotechnology. 5(1); 2017: 74-76.
- Prajakta S. Nawale, Atul A. Shirkhedhar, Sanjay J. Surana, Amod S. Patil. Normal and reversed-phase HPTLC Methods for simultaneous estimation of Telmisartan and Metoprolol Succinate in Pharmaceutical formulation. ISRN Analytical Chemistry. 2011: 1-7.
- Kalaiselvi P, Vijay Amirtharaj R, Venkatachalam T, Senthil Kumar N. HPTLC Method for Simultaneous Determination of Pioglitazone HCl and Telmisartan in Tablet Dosage Form. Asian Journal of Research in Chemistry. 3(1); 2010: 60-62.
- Kokilambigai KS, Seetharaman R, Kavitha J, Sowndaravel P, Lakshmi KS. Multivariate Calibration technique for the spectrophotometric quantification of Zaleplon in bulk and pharmaceutical formulations. Journal of Pharmceutical Sciences and Research. 9(6); 2017: 824 - 829.
- ICH, Q2 (R1), Validation of analytical procedures: text and methodology, International Conference on Harmonization, Geneva, 2005: 1- 13.
- Validation of Telmisartan by UV Spectrophotometry Method
Abstract Views :176 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, IN
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2413-2415Abstract
A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The zero order spectra of Telmisartan in 0.1N NaOH shows λmax at 295.0 nm and estimation was carried out by A(1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2=0.999) over the concentration range of 4-24 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine analysis.Keywords
Telmisartan, 0.1N NaOH, UV-Spectrophotometric.References
- Ajit Pandey, H. Sawarkar, Mukesh Singh, Dr. P Kashyap, Priyanka Ghosh. UV- Visible Spectrophotometric Method for estimation of Telmisartan in Bulk and Tablet Dosage Form. International Journal of Chem Tech Research.2011;3(2): 657-660.
- Dharmendra K. Damor, Rajashree C. Mashru. Method development and validation of simultaneous estimaton of cilostazol and Telmisartan. International Bulletin of Drug Research. 2015:5(8): 12-22.
- K. Sonia, Dr. M. Nappinnai, Dr. P. Panneerselvam. Stability indicating Method Development and Validation of Telmisartan and Ramipril by UV Spectrophotometry. Research J. Pharm. and Tech.2018: 11(7): 3087-3090.
- K. P. Hirpara, Dave V. M., Dr. S. D. Faldu, Dr. B. D. Patel. UVSpectrophotometric Determination for Simultaneous Estimation of Amlodipine Besylate and Telmisartan in Combination. Journal of Pharmaceutical Science and Bioscientific Research.2012:2(3):133137.
- Mayur Modi, Rikin Shah and R.C. Mashru. Development and Validation Of Spectrophotometric Methods For Simultaneous Estimation Of Metoprolol Succinate And Telmisartan In Combined Pharmaceutical Formulation. International Journal Of Pharmaceutical Science and Research. 2012:3(5): 1348-1354.
- Riddhi Patel, Dilip G. Maheshwari. UV Spectrophtometric Methods For Simultaneous Estimation Of Telmisartan And Cilostazol In Synthetic Mixture. Pharma Science Monitor. 2015: 6(1):276-291.
- Sonia K, Manikandan K, Hamunyare Ndwabe, Peddamadi Bhavya Sree, Lakshmi KS. Method Development and Validation of simultaneous estimation for Amlodipine besylate and Olmesartan medoxomil by HPTLC method. International Journal of Research in Pharmaceutical Sciences.2018: 9(1): 201-205.