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Jadhav, K. R.
- Novel Floating Insitu gel of Antihyperlipidemic Agent
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Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1086-1090Abstract
Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.Keywords
Simvastatin, gastroretentive, insitu Gel.
References
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- Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin:A Technical Note
Abstract Views :310 |
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Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3397-3404Abstract
The objective of the present study was to develop self emulsifying drug delivery system of simvastatin to improve solubility and dissolution rate of simvastatin. Simvastatin in a BCS class II drug (poor solubility, good permeability) and low bioavailability (less than 5%). In present study simvastatin self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of simvastatin.Keywords
Emulsification, Solubility, Particle Size.References
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