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Lakshmi Prasanna, J.
- Malabsorption of Drugs in Gastrointestinal Diseases: a Review
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Authors
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1 Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN
1 Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN
Source
Research Journal of Pharmacy and Technology, Vol 6, No 1 (2013), Pagination: 29-33Abstract
Most long term treatments follow the oral administration due to its ease and convenience of administration. After oral administration of any drug, the plasma concentration time curve is a function of many simultaneously operating kinetic processes. The steady state plasma concentration is achieved when the amount of drug absorbed equals the amount of drug eliminated. Both amount and rate of drug absorbed may be altered by diseases which in turn alter other kinetic processes. The amount of drug absorbed is simultaneously affected by physicochemical factors of drug and physiological factors that operate in gut which are also altered by the disease state. The present review focuses on the way in which the absorption of drugs is altered in various conditions of gastro intestinal tract.Keywords
Gastric Emptying Rate, Malabsorption, Peak Plasma Concentration, Metaclopramide
References
- Peter welling G, Francis Tse LS and Shrikant Dighe V. Pharmaceutical bioequivalence. Marcel Dekker.Inc., New York. 2006; pp. 67-88.
- Venkateswarlu V. Biopharmaceutics and pharmacokinetics. Pharmamed press, Hyderabad. pp.58.
- Roert Notari E. Biopharmaceutics and pharmacokinetics an introduction. Marcel Dekker.Inc., New York. 2005; pp. 141-142.
- Parsons RL. Drug absorption in gastro intestinal disease with particular reference to malabsorption syndromes. Clinical pharmacokinetics. 2(1); 1977: 45-60.
- Chisholm GD, Watertworth PM, Calnan JS and Garrod LP. Concentration of antimicrobial agents in intestinal tissue fluid. British medical journal. 1; 1973: 569-573.
- Parsons RL and Paddock GM. Aborption of two antimicrobial drugs, cephalexin and co-trimazole in malabsorption syndromes. Journal of antimicrobial therapy. 1 (1); 1975: 59-67.
- Harsha mohan. The gastro intestinal tract in textbook of pathology. Jaypee brothers medical publishers (p) ltd., New Delhi. 2010; 6th ed: pp.538-591.
- Ross and Wilson. Anatomy and Physiology in health and illness. Churchill Living Stone, New York. 2007; 10th ed: pp.281 – 335.
- Madan PL. Biopharmaceutics and pharmacokinetics. Jaypee brother’s medical publishers (p) ltd., New Delhi. 2000; pp.112.
- Jussila J, Matilla MJ and Takki S. Drug absorption during lactose induced intestinal symptoms in patients with selective lactose malabsorption. Annals medicine experimentalist. Biologiae fenniae. 48; 1970: 33-37.
- Nelson JD, Shelton S Kusmiesz HT and Haltalin K. Absorption of ampicillin and nalidixic acid by infants and children with acute shigellosis. Clinical pharmacology and therapeutics. 13; 1972: 879-886.
- Haiverson L, Doterall G and Wallan A. gastric Emptying in patients with achlorhydria or hyposecretion of hydrochloric acid. Scandinavian journal of gastroenterology. 8; 1973: 395-399.
- Parsons RL, Hossack GA and Paddock GM. The absorption of antibiotics in adult patients with celiac disease. Journal of antimicrobial chemotherapy. 1; 1975: 39-50.
- Parsons RL, Jusko WJ and Lewis GP. Pharmacokinetics of antibiotic absorption in coeliac disease. Journal of antimicrobial chemotherapy. 2(2); 1976: 214-215.
- Parsons Rl, Kaye CM, Raymond K, Trounce TR and Turner P. Absorptio of propanolol and practolol in celiac disease. Gut. 17(2); 1976: 139-143.
- Parsons RL, Hossack GA, Paddock GM and Hailey Dm. In Williams and Geddes, editors. Antibiotic absorption inchrons disease: Chemotherapy Pharmacology of antibiotics. Plenum press, New York. 1976; Vol 4: pp.219-229.
- Anthonisen P, Barany F, Folken borg O, Holtz A, Jarnum S, Kristenson M, Riss P, Walan A and Worning H. The clinical effect of salazosulpapyridine (salazopyrin) in crohn’s disease A controlled blind study. Scandinavian journal of gastroenterology. 9; 1974: 549-554.
- Goldman P, Peppercorn MA and Goldin BR. In Morselli, cohen and Garatti editors. Drugs metabolized by intestinal microflora: Drug interactions. Raven Press, New York. 1974; pp.91.
- Bushby SRM and Hitchings GH. Trimethoprim, a sulphonamide potentiator. British journal of pharmacology and chemotherapy. 33, 1968: 72-90.
- Roert Notari E. Biopharmaceutics and pharmacokinetics an introduction. Marcel dekker.Inc. New York. 2005; pp. 160-162.