Research Journal of Pharmacy and Technology

Chinmaya Keshari Sahoo ¹, Surepalli Ram Mohan Rao ², Muvvala Sudhakar ³, Kokkula Satyanarayana ⁴

Affiliations
1 Pharmaceutics Department, University College of Technology, Osmania University, Hyderabad, Telangana-500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana-500088, IN

Abstract

The present work was aimed to develop and evaluate controlled porosity osmotic pump (CPOP) tablets of an anti HIV drug zidovudine to provide a uniform concentration of drug at absorption site. The formulations were prepared by wet granulation method using drug, various excipients, controlled release polymer hydroxylpropylmethyl cellulose(HPMCE5M LV) and osmogen (Fructose).The CPOP tablets consist of an osmotic core coated with a micro porous membrane made up of cellulose acetate(CA) which is incorporated with sorbitol as porogen. Prior to compression the prepared granules were evaluated for pre compression parameters such as angle of repose, bulk density, tapped density, Carr's index and Hausner's ratio. After compression the prepared granules were evaluated for thickness, coat thickness, hardness, weight variation, friability, drug content, diameter, in vitro drug release study and scanning electron microscopy (SEM) study. The release kinetics for different formulations were analyzed using zero order model equation, first order model equation, Higuchi model equation, Korsmeyer Peppas model equation and Hixson-Crowell equation. The optimized formulation of drug release was independent of pH, agitation intensity, but dependent on the osmotic pressure of the release media. Based on the in vitro dissolution profile optimized formulation ZF4 exhibited Fickian transport mechanism with a drug release of 97.83% in 16 hrs. FTIR and DSC study revealed that there was no interaction between drug and excipients. Formulations subjected to stability testing (at 40±2°C/75±5% RH) as per ICH guidelines for three months indicated stability with no significant changes in thickness, hardness, weight variation, friability drug content and dissolution profiles.

Keywords

CPOP, Zidovudine, Cellulose Acetate, SEM, DSC.

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Chinmaya Keshari Sahoo ¹, D. Venkata Ramana ², Nalinikanta Sahoo ³, Kanhu Charan Panda ⁴, Uttam Prasad Panigrahy ⁵

Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
2 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, IN
4 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN

Abstract

The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentrations of cross carmelose sodium (CCS) as superdisintegrant with a view to gain rapid disintegration in gastric pH for treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML).Five different formulations of Dasatinib immediate release tablets were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 5% CCS gave maximum amount of drug release of 99.14%.Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies reveled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2°C/75±5% RH) on the best formulation indicated that there no significant changes in drug content.

Keywords

Immediate Release Tablets, Dasatinib, CCS, in Vitro Drug Release Study, FTIR Spectroscopy.

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Kanhu Charan Panda ¹, Niranjan Panda ¹, Chinmaya Keshari Sahoo ², Jimidi Bhaskar ³, D. Venkata Ramana ⁴

Affiliations
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN

Abstract

The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.

Keywords

IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.

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