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Abas, Al-Shimaa M.
- Evaluation of Clinical Significance of Kallistatin and Macrophage Inflammatory Protein-1B for the Diagnosis of Liver Cirrhosis and Hepatocellular Carcinoma in Egyptian Patients
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Authors
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1 Biochemistry Division, Chemistry Department, Zagazig University, EG
2 Medical Analysis Specialist, Zagazig University, 01224112677, EG
1 Biochemistry Division, Chemistry Department, Zagazig University, EG
2 Medical Analysis Specialist, Zagazig University, 01224112677, EG
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 43-49Abstract
Background: Early diagnosis of liver diseases especially hepatocellular carcinoma is very important. Cirrhosis is diagnosed clinically by using of laboratory analysis and imaging data, and liver biopsy. However, these methods have their limitations. These findings suggest the need for diagnostic biomarkers that could add to the sensitivity and accuracy. Serum Kallistatin may fall into this category of biomarkers as the liver represents the major site of synthesis and secretion of it and their levels reflect the synthetic function of liver. Objective: To assess serum Kallistatin and CCL4 levels in cases of liver cirrhosis due to any factor and hepatocellular carcinoma. Methods: Sixty patients who were included and classified into 30 patients with liver cirrhosis, 40 patients with hepatocellular carcinoma. They were compared with 20 sex and age matched healthy individuals for control. Levels of serum kallistatin was measured by enzyme-linked immunosorbent assay and serum cholinesterase was measured using colorimetric assay. Results: There was a highly significant decrease in serum Kallistatin and high significant increase of CCL4 in patients with liver cirrhosis when compared with control (P<0.000). However, there was a slight but not significant increase in kallistatin level in HCC group compared with control and significant increase in CCL4 level in HCC group compared with control. Conclusion: Both serum kallistatin and CCL4 can be used as reliable biomarkers for the diagnosis of, evaluation of the extent of liver cirrhosis and hepatocellular carcinoma.Keywords
Kallistatin, CCL4, Liver Cirrhosis, Hepatocellular Carcinoma.
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- Ginger Extract Protect Iodinated Contrast Media Nephrotoxicity in rats through Modulation of Oxidative Stress, Cystain C, NGAL and TNF α
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Authors
Affiliations
1 Chemistry Department, Zagazig University, EG
2 Biochemistry Division, Chemistry Department, Zagazig University, EG
1 Chemistry Department, Zagazig University, EG
2 Biochemistry Division, Chemistry Department, Zagazig University, EG
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 175-184Abstract
Background: Nephrotoxicity was reported in the initial clinical trials of contrast media. Aim of study: Our study was designed to evaluate the protective effect of ginger extract against nephrotoxicity induced by contrast agent. Material and Methods: Animals were divided into 5 groups as follow: Group1 (Control): They were not received any treatment during experiment period. Group2 (Ginger): Animals were deprived from water for 72 hours , then orally administrated with 400 mg/Kg/day of ginger extract for 72 hours. Group3 (protective): Animals were pre administrated orally with ginger extract with 400 mg/Kg for one week, then rats were deprived of water for 72 hours, then urografin was induced by a single (I.V.) at dose of 10mL per kg after that animals were orally administrated with 400 mg/Kg/day of ginger extract for 3 consecutive days. Group 4 (positive)(contrast media): Animals were induced by a single intravenous (I.V.) of urografin at dose of 10mL per kg after deprivation of water for 72 hours. Group 5(therapeutic): Animals rats were deprived of water for 72 hours, then Contrast-induced nephrotoxicity was induced (as group 4) , after that animals were post administrated with ginger extract 400 mg/Kg (for 3 days). Results: Administration contrast media caused significant elevation in serum urea, creatinine concentration, kidney tissue levels of MDA and NO. Also it caused significant increase in Cystain C , NGAL and TNFα levels. Also it significantly decreased SOD activity and GSH level. Treatment with Ginger extract restored the elevation of concentration of urea and creatinine, also oxidative stress markers in groups 3 and 5 and decreased Cystain C, NGAL and TNFα levels. Histopathological analysis confirmed that. Conclusion: ginger extract have a protective role in contrast media induced nephrotoxicity.Keywords
Nephrotoicity, Diatrizoate, Ginger, Cystain C, NGAL, TNFα.References
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