Research Journal of Pharmacy and Technology

Ankit Patel ¹, Pankaj Kushwah ¹, Sujit Pillai ¹, Ajay Raghuvanshi ¹, Nitin Deshmukh ¹

Affiliations
1 GRY Institute of Pharmacy, Borawan, Khargone, IN

Abstract

Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Herbal formulations have growing demand in the world market. The present work deals with the development&evaluation of the herbal hand wash containing ethanolic extract of liquorice ischolar_main (Glycyrrhiza glabra). Hand-washing is very important process in day to day life. Hands are major source through which microbial infections may occur thus proper hand was must be required using appropriate hand wash formulation. Herbs are known to have antimicrobial properties thus utilization of such herbs as antimicrobial agent is a common practice now. Present study involves formulation of herbal hand wash using extract of liquorice ischolar_main (Glycyrrhiza glabra). Disc diffusion method was utilized for evaluation of the antimicrobial activity against skin pathogens of the prepared herbal hand. Its efficacy was checked and compared with the standard commercial hand wash. Results revealed that extract of liquorice ischolar_main (Glycyrrhiza glabra) formulation was more efficient in reducing the number of organisms from hands based handwash with less or no side effects. Thus, owing to higher antimicrobial activity efficacy these herbal extract can be used in the preparation of herbal hand wash on commercial scale.

Keywords

Hand Wash, Antimicrobial Activity, Glycyrrhiza glabra.

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Ajay Raghuvanshi ¹, D. M. Kar ¹, Prabhat Das ², Renu Bala ²

Affiliations
1 School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar, Odisha, IN
2 GRY Institute of Pharmacy, Borawan, Khargone, IN

Abstract

Scientific validation of much medicinal flora is lacking in India and still many species are used traditionally. From many years Ipomoea reniformis was studied for its traditionally claimed activity and still it is unexplored. The plant can be further explored for the study of traditionally claimed unexplored activities, as well as isolation and identification of active constituents may lead to new findings. In the present study whole plant of I. reniformis was collected, dried and extracted with various solvents according to solubility index, and finally five extracts were studied by well diffusion assay for their antifungal and antimicrobial effects on both gram positive, gram negative bacteria and a fungal species. The study revealed that ethyl acetate extract was having highest activity that is why fractions of the ethyl acetate extract was prepared by various solvents and again the antimicrobial study was done with each fraction. The ethyl acetate extract and fraction exhibited activity against both Gram positive and Gram negative bacteria, while the aqueous extracts elucidated antimicrobial activity against only Staphylococcus aureus. The ethanolic and chloroform extracts showed inhibition of Aspergillus niger. The plant showed antimicrobial activity, evidencing the need to conduct further studies that can identify their active components responsible for the activity.

Keywords

Ipomoea reniformis, Antimicrobial Activity, LCMS, IR and NMR.

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