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Bairi, Agaiah Goud
- Development, In-Vitro and Ex-Vivo Evaluation of Muco-Adhesive Buccal Patches of Candesartan Cilexetil
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Authors
Affiliations
1 Vaagdevi Pharmacy College, Bollikunta, Warangal, IN
2 Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, IN
3 SRR College of Pharmaceutical Sciences, Valbhapur, Warangal, IN
1 Vaagdevi Pharmacy College, Bollikunta, Warangal, IN
2 Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, IN
3 SRR College of Pharmaceutical Sciences, Valbhapur, Warangal, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3038-3044Abstract
Candesartan cilexetil (CC), is an anti-hypertensive drug belongs to angiotensin-II receptor antagonist. CC possesses poor oral bioavailability due to first-pass metabolism and poor aqueous solubility. Various approaches are known to reduce the problems of first-pass metabolism. Hence, buccal drug delivery was an approach to improve bioavailability. The present study, buccal muco-adhesive patches were prepared by using hydroxyl propyl methyl cellulose (HPMC E15) and eudragit RLPO and evaluate for physicochemical properties, such as thickness, weight uniformity, folding endurance, drug content, surface pH, swelling index, moisture absorption and ex vivo permeation studies. Among all the formulations, F7 was selected as an optimized formulation and was found to be 100.55% of drug in 6 hrs, and exhibited controlled drug release, follows zero-order kinetics with diffusion as a release mechanism. The ex-vivo permeation studies revealed that 100% of drug permeated in 6 hrs. Therefore, the buccal patches of CC were successfully developed and enhancement in oral bioavailability is further confirmed by conducting in-vivo studies.Keywords
Candesartan Cilexetil, First-Pass Metabolism, Buccal Muco-Adhesive Patches, In-vitro, ex-vivo.
References
- Narendar D and Kishan V. Candesartan cilexetil nanoparticles for improved oral bioavailability. Ther deli, 2017; 8(2):79-88.
- Ettireddy S, Reddy ND. Influence of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrinon Enhancement of Solubility and Dissolution of Isradipine. Int J Pharm Sci Nanotech 2017; 10(3):3752-3757.
- Palem CR, Reddy ND, Satyanarayana G, Varsha BP. Development and optimization of Atorvastatin calcium-cyclodextrin inclusion complexed oral disintegrating tablets for enhancement of solubility, dissolution, pharmacokinetic and pharmacodynamic activity by central composite design. Int J Pharm Sci Nanotech 2016; 9(2): 1-11.
- Arun B, Narendar D. Enhancement of solubility and dissolution rate of trandolapril sustained release matrix tablets by liquisolid compact approach. Asian J Pharm 2015; 9 (4); 290-297.
- Narendar D and Kishan Veerabrahma. Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation. Drug Delivery, 2016, 23 (2); 395-404.
- Bomma R, Arjun N, Karthik Yadav J. Amoxycillin trihydrate floating-bioadhesive drug delivery system for eradication of helicobacter pylori: preparation, in vitro and ex vivo evaluation. J bioequ avail 2016; 8(3): 118-124.
- Pitta S, Dudhipala N, Narala A and Veerabrahma K. Development and evaluation of zolmitriptan transfersomes by Box-Behnken design for improved bioavailability by nasal delivery. Drug Dev Ind Pharm2018;44(3):484-492.
- Nagaraj K, Narendar D, Kishan V. Development of olmesartan medoxomil optimized nanosuspension using Box-Behnken design to improve oral bioavailability. Drug Dev Ind Pharm 2017; 43(7):1186-1196.
- Senel S and Hincal AA. Drug penetration enhancement via buccal route; possibilities and limitations. J Control Release.2001, 72:133-144.
- Vishnu M. Patel, Bhupendra G. Prajapati, and Madhabhai M. Patel, Effect of Hydrophilic Polymers on Buccoadhesive Eudragit Patches of Propranolol Hydrochloride Using Factorial Design, AAPS Pharm Sci Tech 2007; 8 (2) Article 45.
- S. Sarojini1, P. Ravikumar, S. Saranya, A. Dhivya, K. Manimaran, B. Jayanthi, M. Komala, Formulation Development of Olmesartan Medoxomil Mucoadhesive Buccal Film, Asian Journal of Pharmaceutics, Oct-Dec 2016 (Suppl), 10 (4), S510.
- Choy Fun Wong, Kah Hay Yuen, Kok Khiang Peh, Formulation and evaluation of controlled release Eudragit buccal patches, International Journal of Pharmaceutics, 178 (1999) 11–22.
- Anders, R, Merkle, H.P, Evaluation of laminated mucoadhesive patches for buccal drug delivery. Int. J. Pharm. 1989, 49, 231–240.
- Noha A N, Nabila A B, Fatma A I, Lobna M M, Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride, Acta Pharm. 53 (2003) 199–212.
- Siriporn Okonogi1, Sakornrat Khongkhunthian, Sanchai Jaturasitha, Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems, Drug Discoveries & Therapeutics. 2014; 8(6):262-267.
- Munish Kumar Dhiman, Anupama Dhiman, and Krutika K. Sawant, Transbuccal Delivery of 5-Fluorouracil: Permeation Enhancement and Pharmacokinetic Study, AAPS PharmSciTech, Vol. 10, No. 1, March 2009.
- Surya N. Ratha Adhikari, Bhabani S. Nayak, Amit K. Nayak, and Biswaranjan Mohanty, Formulation and Evaluation of Buccal Patches for Delivery of Atenolol, AAPS Pharm Sci Tech, Vol. 11, No. 3, September 2010.
- Parthasarathy Govindasamy, Bhaskar Reddy Kesavan, Jayaveera Korlakunta Narasimha, Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa, Asian Pac J Trop Biomed 2013; 3(12): 995-1002.
- Chinna Reddy Palem, Ramesh Gannu, Narender Doodipala, Vamshi Vishnu Yamsani, and Madhusudan Rao Yamsani, Transmucosal Delivery of Domperidone from Bilayered Buccal Patches: In Vitro, Ex Vivo and In Vivo Characterization, Arch Pharm Res Vol 34, No 10, 1701-1710, 2011.
- Himabindu P, Narendar D, Krishna Mohan C, Nagaraju B. Transmucosal delivery of duloxetine hydrochloride for prolonged release: preparation, in vitro, ex vivo Characterization and in vitro-ex vivo CorrelationInt J Pharm Sci Nanotech 2018, 11(5), 4249-4258.
- Shaikh Ershadul Haque, Angappan Sheela, Development of polymer-bound fast-dissolving metformin buccal film with disintegrants, International Journal of Nanomedicine, 2015:10 (Suppl 1), 199–205.
- Verma N, Wahi AK, Verma A, Chattopadhayay P. Evaluation of a mucoadhesive buccal patch for delivery of atenolol: in vitro screening of bioadhesion. J Pure Appl Microbiol. 2007;1:115–8.
- Bottenberg P, Cleymaet R, Muynek CD, Remon JP, Coomans D, Slop D. Development and testing of bioadhesive, fluoride-containing slow-release tablets for oral use. J Pharm Pharmacol. 1991; 43: 457-464.
- Semalty A, Semalty M, and Nautiyal U, Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate, Indian J Pharm Sci. 2010; 72(5): 571–575.
- Parthasarathy Govindasamy, Bhaskar Reddy Kesavan, Jayaveera Korlakunta Narasimha, Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa, Asian Pac J Trop Biomed 2013; 3(12): 995-1002.
- Varsha Agarwal, B.Mishra. Design and development and biopharmaceutical properties of buccoadhesive compacts of pentazocaine. Drug. Dev. Ind. Pharm, 1999, 25(6): 701-9.
- Surya N. Ratha Adhikari,1 Bhabani S. Nayak,1 Amit K. Nayak,2 and Biswaranjan Mohanty2,3, Formulation and Evaluation of Buccal Patches for Delivery of Atenolol, AAPS Pharm Sci Tech, Vol. 11, No. 3, September 2011.
- Attama A, Akpa PA, Onugwu LE, Igwilo G. Novel buccoadhesive delivery system of hydrochlorothiazide formulated with ethyl cellulose hydroxypropyl methylcellulose interpolymer complex. Scientific Res Essay. 2008;3(6):26–33.
- Shaikh Ershadul Haque, Angappan Sheela, Development of polymer-bound fast-dissolving metformin buccal film with disintegrants, International Journal of Nanomedicine 2015:10 (Suppl 1: Challenges in biomaterials research) 199–205.
- Amal Hassan El-Kamel,1 Lubna Y. Ashri,1 And Ibrahim A. Alsarra1 Micromatricial Metronidazole Benzoate Film As A Local Mucoadhesive Delivery System For Treatment of Periodontal Diseases AAPS Pharmscitech 2007; 8 (3) Article 75.
- J Thimmasetty*,GS Pandey and PR Sathesh Babu Design and In-vivo Evaluation of Carvedilol Buccal Mucoadhesive Patches Pak. J. Pharm. Sci., Vol.21, No.3, July 2008, Pp.241-248.
- Padula CP, Colombo G, Nicoli S, Catellani PL, Massimo G, Santi P. Bioadhesive Film for the Transdermal Delivery of Lidocaine: In Vitro nd In Vivo Behavior. J Control Release. 2003;88:277Y285.
- Peh KK, Wong CF. Polymeric Films as Vehicle for Buccal Delivery: Swelling, Mechanical, and Bioadhesive Properties. J Pharm Pharm Sci. 1999;2:53Y61.
- Puratchikody A, Prasanth VV, Sam TM, Ashok BK. Mucoadhesive patches of salbutamol sulphate for unidirectional buccal drug delivery: Development and evaluation. Curr Drug Deliv. 2011;8:416–425.
- V.V. Prasanth, A. Puratchikody, S.T. Mathew, and K.B. Ashok, Effect of permeation enhancers in the mucoadhesive buccal patches of salbutamol sulphate for unidirectional buccal drug delivery, Res Pharm Sci. 2014 Jul- Aug; 9(4): 259–268.
- Nakamura F, Ohta R, Machida Y, Nagai T. In vitro and in vivo nasal mucoadhesion of water soluble polymers. Int. J. Pharm. 1996; 134:173-81.