Research Journal of Pharmacy and Technology

V. Velmurugan ¹, T. Sundarrajan ¹, A. Chandran ², G. Arunachalam ²

Affiliations
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, IN
2 PGP College of Pharmaceutical Science and Research Institute, Namakkal, Tamilnadu, IN

Abstract

In this work we studied the diuretic potential of aqueous and ethanolic leaves extract of Cardiospermum halicacabum Linn in experimental Wister rats. The ethanolic extract was done by Continuous Hot Percolation method and the aqueous extract was done by Maceration method. Both aqueous and ethanolic Extract of Cardiospermum halicacabum Linn was tested to check the presence of different active constituents like alkaloids, flavonoids, glycosides, terpenoids and saponins. The aqueous and ethanolic leaves extract Cardiospermum halicacabum Linn was used for diuretic activity at the dose 200 mg/kg was compared with standard drug furosemide (10 mg/kg). Various ion concentrations like Sodium, Potassium, Chloride and urine volume was measured. Urine volume increases in aqueous extract than the ethanolic extract. Both the extract showed more urine volume when compared to control but less than that of standard drug. The significant increases in Sodium, Potassium and Chloride ion concentration in both the extract group.

Keywords

Cardiospermum halicacabum Linn, Continuous Hot Percolation, Diuretic activity, Furosemide.

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