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Badruddeen,
- Solasodine:A Perspective on their roles in Health and Disease
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1 Kamla Nehru Institute of Management and Technology, Sultanpur, IN
2 Integral University, Lucknow 226026, IN
1 Kamla Nehru Institute of Management and Technology, Sultanpur, IN
2 Integral University, Lucknow 226026, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2571-2576Abstract
Steroidal glycoalkaloids, a category of glycosidic ingradients are originated from nitrogen-containing steroids. Structurally it includes of C27 cholestane skeleton to that 1 to 5 sugar moieties are hooked up at the 3-OH region of the aglycone part. Solasodine, in most of the solanaceous plants occurs as an aglycone a region of glycoalkloids, like solasonine, solamargine etc. Solasodine is employed as a hormone precursor within the steroid drug business for the manufacturing corticosteroids, anabolic steroids, antifertility drugs etc. Isolated Solasodine from solanum plants exploits its medicinal properties such as anticonvulsant, CNS depressant, antioxidant, cytotoxic, antinociceptive, anti-inflammatory, hepatoprotective, immunomodulatory, antiatherosclerotic, antimicrobial, and antiobesity activity, etc. In acut toxicity study, LD50 of Solasodine was found to be 1500 mg/kg after intraperitoneal administration and 2000 mg/kg, after oral administration in rats. Present review has set about to bring updated information regarding to pharmacological activities of solasodine, which may be helpful to researchers to explore a new bioactive molecules for various therapeutic application.Keywords
Solasodine, Spiroketal, Steroidal Glycoalkaloids, Pharmaco-therapeutics.References
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- Evaluation of Dermatological Adverse Drug Reactions in a Tertiary Care Hospital of Northern India
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Authors
Affiliations
1 Department of Pharmacology and Therapeutics, GSVM Medical College, Kanpur (U.P), IN
2 Integral University, Lucknow (U.P), IN
1 Department of Pharmacology and Therapeutics, GSVM Medical College, Kanpur (U.P), IN
2 Integral University, Lucknow (U.P), IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3517-3521Abstract
In clinical practice dermatological reactions are common but comprehensive information regarding their incidence, severity is often not available as many cases go unreported. The objective of this study was to evaluate the types of dermatological adverse drug reactions (ADRs) in a tertiary care hospital and determine their causal relationship with the offending drug. This prospective, observational study was conducted at GSVM medical college Kanpur, Northern India for one year. Patients of all age and either sex were included. Dermatological adverse drug reactions were reported by the physicians of various department of the hospital and their causality assessments were performed as per World health organization (WHO) Uppsala monitoring centre (UMC), Expanded Rawlins and Thompson’s classification was used for determining type of ADRs, outcome and seriousness of ADR were assessed as per WHO. Descriptive statistics were used for data analysis. A total of 105 dermatological adverse drug reactions were reported from various departments of this tertiary care hospital. Most of the adverse drug reactions were observed in the age group of 0–20 year. Rash (35 ADRs) was commonly reported reaction. Anticancer drugs lead to 48 ADRs (mainly with Paclitaxel+Carboplatin-11, Adriamycin+Cyclophosphamide-7), followed by Antibacterial with 28 ADRs (mainly with Vancomycin-6, Cefixime-4 and Amoxicillin-4). A total of 8 ADRs were of serious type mainly with Vancomycin-Red man syndrome-6, Carbamazepine-toxic epidermal necrolysis-1 and Nimesulide-Steven Johnson Syndrome-1. Most of the adverse drug reactions on causality assessment were possible (77, 73.33%) and Probable (28, 26.67%) in nature. Type -B ADRs account for 2/3rd of the total dermatological ADRs. It’s highly emphasized for careful monitoring for ADRs associated with high risk drugs and more awareness should be created.Keywords
Adverse Drug Reaction, Causality, Dermatological, Rash.References
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