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Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats


Affiliations
1 Geomatika University College Kuala Lumpur, 54200, Malaysia
2 Department of Pharmacology, MAHSA University, 42610, Malaysia
3 UCSI University, Kuala Lumpur, 56000, Malaysia
     

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Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods and Material: Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia. Statistical analysis : Data were analysed by One - way ANOVA, followed by Turkey –Kramer Multiple Comparison Test. Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.

Keywords

Dolichandrone atrovirens, Streptozotocin, in Vivo Activity, Antidiabetic.
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  • Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats

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Authors

Saminathan Kayarohanam
Geomatika University College Kuala Lumpur, 54200, Malaysia
Vetriselvan Subramaniyan
Department of Pharmacology, MAHSA University, 42610, Malaysia
Ashok Kumar Janakiraman
UCSI University, Kuala Lumpur, 56000, Malaysia
S. J. Madhan Kumar
UCSI University, Kuala Lumpur, 56000, Malaysia

Abstract


Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods and Material: Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia. Statistical analysis : Data were analysed by One - way ANOVA, followed by Turkey –Kramer Multiple Comparison Test. Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.

Keywords


Dolichandrone atrovirens, Streptozotocin, in Vivo Activity, Antidiabetic.

References