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Cytotoxic Effect of Allium cepa L. Extract on Human colon Cancer (WiDr) Cells:In Vitro Study


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1 Universitas Airlangga, Surabaya, 60115, Indonesia
     

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The extract of Allium cepa L. is commonly used as adjuvant therapy for cancer that includes a potential source of anticancer properties. This study aimed to evaluate the cytotoxicity from a crude extract of Allium cepa L. against human colon cancer (WiDr) cells. The cytotoxic effect of Allium cepa L. extract was determined using MTT assay. The Allium cepa L. extract inhibited the proliferation of WiDr cells, but revealed no potent cytotoxicity with IC<50 value of 1363.29 μg/mL on WiDr cells. The results showed that Allium cepa L. extract was no longer active as an anticancer drug, but it would be more active using the direct-bioactive compound of Allium cepa L. Some intens observations are still required to maximize its potential as one of chemotherapeutic agents in the future. On the other hand, further studies are needed to obtain the right dose of Allium cepa L. extract that can inhibit the cell growth well and determine the accuracy of its mechanism on WiDr cells as one of therapeutic strategies to treat human colon cancer.

Keywords

Allium cepa L, WiDr Cells, Cytotoxic.
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  • Cytotoxic Effect of Allium cepa L. Extract on Human colon Cancer (WiDr) Cells:In Vitro Study

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Authors

Amaq Fadholly
Universitas Airlangga, Surabaya, 60115, Indonesia
Arif N. M. Ansori
Universitas Airlangga, Surabaya, 60115, Indonesia
Shara Jayanti
Universitas Airlangga, Surabaya, 60115, Indonesia
Annise Proboningrat
Universitas Airlangga, Surabaya, 60115, Indonesia
Muhammad K. J. Kusala
Universitas Airlangga, Surabaya, 60115, Indonesia
Naimah Putri
Universitas Airlangga, Surabaya, 60115, Indonesia
Fedik A. Rantam
Universitas Airlangga, Surabaya, 60115, Indonesia
Sri A. Sudjarwo
Universitas Airlangga, Surabaya, 60115, Indonesia

Abstract


The extract of Allium cepa L. is commonly used as adjuvant therapy for cancer that includes a potential source of anticancer properties. This study aimed to evaluate the cytotoxicity from a crude extract of Allium cepa L. against human colon cancer (WiDr) cells. The cytotoxic effect of Allium cepa L. extract was determined using MTT assay. The Allium cepa L. extract inhibited the proliferation of WiDr cells, but revealed no potent cytotoxicity with IC<50 value of 1363.29 μg/mL on WiDr cells. The results showed that Allium cepa L. extract was no longer active as an anticancer drug, but it would be more active using the direct-bioactive compound of Allium cepa L. Some intens observations are still required to maximize its potential as one of chemotherapeutic agents in the future. On the other hand, further studies are needed to obtain the right dose of Allium cepa L. extract that can inhibit the cell growth well and determine the accuracy of its mechanism on WiDr cells as one of therapeutic strategies to treat human colon cancer.

Keywords


Allium cepa L, WiDr Cells, Cytotoxic.

References