Research Journal of Pharmacy and Technology

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Development of Natural Gum based Sustained Release Tablets of Propranolol Hydrochloride


Affiliations
1 Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
     

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Objective: The objective of this work was to investigate the film coating potential of natural and modified, tamarind seed gum and fenugreek seed gum using propranolol HCl as model drug. Materials and Methods: Tamarind seed gum (TG), fenugreek seed gum (FG), sodium trimeta phosphate (STMP), propranolol HCl, hydroxypropyl methylcellulose (HPMC), sodium- alginate (SA). Core tablets of propranolol HCl were prepared and evaluated for weight, disintegration time, diameter, hardness, friability and disintegration time. The core tablets were coated using 2% w/v solution of TG, MTG, FG, MFG. The in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Result: The tablets coated with natural and modified tamarind seed gum sustained the release of the drug up to 11hrs and 12hrs, respectively and natural and modified fenugreek seed gum sustained release of the drug up to 8hrs and 10 hrs respectively. The tablets coated with HPMC sustained release of the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile it is concluded that unmodified and modified TSG can be used as release rate controlling membrane.

Keywords

Tamarind Seed Gum, Fenugreek Seed Gum, Natural Polymer.
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  • Sauer D, Watts AB, Coots LB, Zheng WC, McGinity JW. Influence of polymeric subcoats on the drug release properties of tablets powder-coated with pre-plasticized Eudragit L 100-55. International Journal of Pharmaceutics 2009, 367: 20-8.

  • Rhodes CT, Porter SC. Coating for controlled-release drug delivery systems. Drug Development and Industrial Pharmacy 1998L, 24: 1139-54.

  • Kwok TS, Sunderland BV, Heng PW. An investigation on the influence of a vinyl pyrrolidone/vinyl acetate copolymer on the moisture permeation, mechanical and adhesive properties of aqueous-based hydroxypropyl methylcellulose film coatings. Chem Pharm Bull 2004, 52:790-6.

  • Rowe RC. The effect of some formulation and process variables on the surface roughness of film-coated tablets. Journal of Pharm Pharmacol 1978, 30: 669-72.

  • Shukla A, Bukhariya V., Mehta J., Bajaj J., Charde R., Charde M, Gandhare B. Herbal Remedies for Diabetes: An Overview. International Journal of Biomedical and Advance Research, 2011, 02(01):57-68.

  • Shukla AK, Kumar M, Bishnoi RS, Jain CP. Application of Fenugreek Seed Gum: In Novel Drug Delivery. Asian Journal of Biomaterial Research 2017, 3(6): 1-10.

  • Nokhodchi A, Khodaparast HNK, Sorkh-Shahan T, Valizadeh H, Ford JL. An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet. Drug Development and Industrial Pharmacy 2008, 34: 323–329.

  • Sav AK, Fule RA, Meer TA, Amin P. Synthesis and evaluation of octenyl succinate derivative of Fenugreek gum as extended release polymer. Journal of Pharmaceutical Investigation 2013, 43(5): 417-429.

  • Nitalikar MM, Patil RA, Dhole SD, Sakarkar DM. Evaluation of fenugreek seed husk as tablet binder. International Journal of Pharmaceutical Research and Development2010, 2(8): 21-23.

  • Nitalikar MM, Patil RA, Dhole SD, Sakarkar DM. Formulation of fenugreek husk as tablet binder. International Journal of Pharmaceutical Research and Development 2013, 43(5): 417-429.

  • Tavakoli N, Varshosaz J, Ghannadi A. Bavarsad N. Evaluation of Trigonella foenum-graecum L seeds gum as a novel tablet binder. International Journal of Pharmacy and Pharmaceutical Sciences 2012, 4(1): 97-101.

  • Nayaka AK, Pal D, Das S. Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl. Carbohydrate Polymers 2013; 96:349–57.

  • Dutta R, Bandyopadhyay AK. Development of a new nasal drug delivery system of diazepam with natural mucoadhesive agent from Trigonella foenum-graecum L. Journal of Science and Industrial Research 2005, 64: 973-977.

  • Senthil V, Sripreethi D. Formulation and Evaluation of Paracetamol Suspension from Trigonella foenum-graecum L Mucilage. Journal of Advanced Pharmacy Education & Research 2011, 1(5):225-233.

  • Olga Kaltsa, Neolea Spiliopoulou, Stavros Yanniotis, Ioanna Mandala, Stability and physical properties of model macro- and nano/submicron emulsions containing fenugreek gum. Food Hydrocolloids 2016, 61:625– 632.

  • Sav AR, Meer TS, Fule RA, Amin PD. Investigational studies on highly purified Fenugreek gum as emulsifying agent. Journal of Dispersion Sciences Technology 2013, 34:657-662

  • Gowthamrajan K, Kulkarni GT, Muthukumar A. Evaluation of Fenugreek mucilage as gelling agent. International Journal of Pharmaceutical Experiment 2002, 3: 16-19.

  • Beraa H, Chakravarthy G, Kumar S, Sarkar S, Boddupallib S, Reddy S. Ippagunta SR. HPMC-based gastroretentive dual working matrices coated with Ca+2 ion cross-linked alginate fenugreek gum gel membrane. Materials Science and Engineering 2016, 67(1):170–181

  • Shukla AK, Bishnoi RS, Dev SK, Manish Kumar, Fenin V, Jain CP. Applications of Tamarind seeds Polysaccharide-based copolymers in Controlled Drug Delivery: An overview Asian Journal of Pharmacy and Pharmacology 2018, 4(1): 23-30

  • Garg A, Garg S, Kumar M, Kumar S, Shukla AK, Kaushik SPC. Applications of natural polymers in mucoadhesive drug delivery: An overview. Advance Pharmaceutical Journal 2018, 3(2): 38-42

  • Ikoni J. Ogaji, Stephen W. Hoag. Novel extraction and application of okra gum as a film coating agent using theophylline as a model drug. Journal of Advanced Pharmaceutical Technology & Research 2014, 5(2): 70-77.

  • Reddy MM, Reddy JD, Moin A, Shivakumar HG. Formulation of Sustained-Release Matrix Tablets Using Cross-linked Karaya Gum. Tropical Journal of Pharmaceutical Research 2012, 11 (2): 185-192


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  • Development of Natural Gum based Sustained Release Tablets of Propranolol Hydrochloride

Abstract Views: 311  |  PDF Views: 0

Authors

Ajay Kumar Shukla
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
Ram Singh Bishnoi
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
Manish Kumar
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
C. P. Jain
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

Abstract


Objective: The objective of this work was to investigate the film coating potential of natural and modified, tamarind seed gum and fenugreek seed gum using propranolol HCl as model drug. Materials and Methods: Tamarind seed gum (TG), fenugreek seed gum (FG), sodium trimeta phosphate (STMP), propranolol HCl, hydroxypropyl methylcellulose (HPMC), sodium- alginate (SA). Core tablets of propranolol HCl were prepared and evaluated for weight, disintegration time, diameter, hardness, friability and disintegration time. The core tablets were coated using 2% w/v solution of TG, MTG, FG, MFG. The in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Result: The tablets coated with natural and modified tamarind seed gum sustained the release of the drug up to 11hrs and 12hrs, respectively and natural and modified fenugreek seed gum sustained release of the drug up to 8hrs and 10 hrs respectively. The tablets coated with HPMC sustained release of the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile it is concluded that unmodified and modified TSG can be used as release rate controlling membrane.

Keywords


Tamarind Seed Gum, Fenugreek Seed Gum, Natural Polymer.

References