Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hydroxycitric Acid (Hca)-A Potent Nutraceuticals


Affiliations
1 Department of Biotechnology, R V College of Engineering, Bengaluru, India
     

   Subscribe/Renew Journal


On a global scale, obesity has reached epidemic proportions and is a major contributor to the global burden of chronic disease and disability [1]. Currently, more than one billion adults worldwide are overweight and at least 300 million of them are clinically obese (WHO, 2018). Currently, there are many treatments available for obesity; one such method involves the use of anti-obese molecules. Compounds such as Orlistat, Lorcaserin, Sibutramine, Metformin and Hydroxycitric acid (HCA) are used as anti-obese molecules. Among these, Hydroxycitric acid is the preferred molecule since it shows high efficacy in controlling obesity, with minimal side effects. Several pharmaceutical companies extract HCA from the fruits of Garcinia cambogia, a native tree grown in south India. Due to geographical and seasonal limitation of Gracinia fruits, an alternative method of producing HCA is necessary.

Keywords

Garcinia cambogia, Hydroxy Citric Acid (HCA), Nuetraceutical, Antiobesity, Orlistat, Lorcaserin, Sibutramine, Metformin.
Subscription Login to verify subscription
User
Notifications
Font Size


  • T. Farhat, R. J. Iannotti, and B. G. Simons-Morton, “Overweight, obesity, youth and health-risk behaviours,” American Journal of Preventive Medicine, vol. 38, no. 3, pp. 258–267, 2010.

  • Richard A Collins hydroxycitric acid, as an weight-loss formulations and appetite-suppressor products the biomedical scientist September 2006

  • R. Revathi, R. Ravi, V. S. Saravanan, T. Ethiraj, T. Sudhamani Isolation and characterization of (-) hydroxy citric acid from garcinia cambogia fruit extract ijprd/pub/arti/vol-2/issue-7/sep/015 2010

  • Kumar, S., Sharma, S. And Chattopadhyay, S.K. Rapid and sensitive HPLC-PDA method for simultaneous identification and quantification of dietary weight reducing compound hydroxy citric acid lactone and chemo preventive compounds isoxanthochymol and xanthochymol in Garcinia indica International Food Research Journal 20(1): 397-402 (2013)

  • Devendra K Chauhan, A k Thkur , A Dass , J M Lima and S K Malik, National bureau of plant Genetic Resources Direct Organogenesis from leaf explants of Garcinia Indica Choisy : An important medicinl plant Indian journal of Biotechnology Vol 11 April pg 215-219 2012

  • S. Ansari, B. Chauhan, N. Kalam and G. Kumar, "Current concepts and prospects of herbal nutraceutical: A review", J Adv Pharm Tech Res, vol. 4, no. 1, p. 4, 2013.

  • Naveen GPAN, Krishnakumar G, “Traditional and Medicinal Uses of Garcinia gummi-gutta Fruit-A Review”, Species, vol. 4, no. 10, pp. 04-05, 2013

  • J. Triscari and A. Sullivan, "Comparative effects of (−)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo", Lipids, vol. 12, no. 4, pp. 357-363, 1977.

  • N. Saadat and S. Gupta, "Potential Role of Garcinol as an Anticancer Agent", Journal of Oncology, vol. 2012, pp. 1-8, 2012.

  • L. Chuah, W. Ho, B. Beh and S. Yeap, "Updates on Antiobesity Effect of Garcinia Origin (−)-HCA", Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1-17, 2013.

  • S. Chen, A. Ogawa, M. Ohneda, R. Unger, D. Foster and J. McGarry, "More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling", Diabetes, vol. 43, no. 7, pp. 878-883, 1994.

  • Subhashini N, Nagarajan G, Kaviman S. “In vitro antioxidant and anticholinesterase activities of Garcinia combogia”, Int J Pharm Pharm Sci, 3:129–32,2011.

  • H. Brunengraber, J. Sabine, M. Boutry and J. Lowenstein, "3-β-Hydroxysterol synthesis by the liver", Archives of Biochemistry and Biophysics, vol. 150, no. 2, pp. 392-396, 1972.

  • S. Heymsfield, D. Allison, J. Vasselli, A. Pietrobelli, D. Greenfield and C. Nunez, "Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent", JAMA, vol. 280, no. 18, p. 1596, 1998.

  • R. Mattes and L. Bormann, "Effects of (−)-hydroxycitric acid on appetitive variables", Physiology and Behavior, vol. 71, no. 1-2, pp. 87-94, 2000.

  • M. Leonhardt, B. Hrupka and W. Langhans, "Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats", Physiology and Behavior, vol. 74, no. 1-2, pp. 191-196, 2001.

  • Hayamizu K, Ishii Y, Kaneko I, Shen M, Okuhara Y, Shigematsu N, Tomi H, Furuse M, Yoshino G, Shimasaki H. “Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial”. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67. doi: 10.1016/j.curtheres.2003.08.006.

  • Kovacs EM, Westerterp-Plantenga MS, Saris WH. “The effects of 2-week ingestion of (--)-hydroxycitrate and (--)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight”. Int J Obes Relat Metab Disord. Jul;25(7):1087-94. 2001.

  • Saito, M., M. Ueno, S. Ogino, K. Kubo, J. Nagata and M. Takeuchi. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem. Toxicol. 43: 411-419. 2005.

  • N. S. Deshmukh,M. Bagchi,T. Yasmin and D. Bagchi “Safety of a Novel Calcium/Potassium Saltof (-)-Hydroxycitric Acid (HCA-SX): II. Developmental Toxicity Study in Rats” Journal Toxicology Mechanisms and Methods Volume 18, 2008 - Issue 5

  • A. Altiner, A. Ates, F. Esen Gursel and T. Bila “Effect of the antiobesity agent garcinia cambogia extract on serum lipoprotein (a), apolipoproteins a1 and b, and total cholesterol levels in female rats fed atherogenic diet”. The Journal of Animal and Plant Sciences, 22(4): 2012, Page: 872-877 ISSN: 1018-7081.

  • Yamada, Hiroyuki Hida, Yasuhiro Yamada Chemistry, physiological properties, and microbial production of hydroxycitric acid- Takashi -Applied Microbiology and Biotechnology July Springer, Volume 75, Issue 5, pp 977-982 2007 .

  • Hiroyuki Hida, Yasuhiro Yamada, Yamada production of Hydroxycitric acid by microorganism Biosci. Biotechnol. Biochem 69(8),1555-1561 2007.


Abstract Views: 474

PDF Views: 0




  • Hydroxycitric Acid (Hca)-A Potent Nutraceuticals

Abstract Views: 474  |  PDF Views: 0

Authors

Narendra Kumar Sura
Department of Biotechnology, R V College of Engineering, Bengaluru, India
Lingayya Hiremath
Department of Biotechnology, R V College of Engineering, Bengaluru, India

Abstract


On a global scale, obesity has reached epidemic proportions and is a major contributor to the global burden of chronic disease and disability [1]. Currently, more than one billion adults worldwide are overweight and at least 300 million of them are clinically obese (WHO, 2018). Currently, there are many treatments available for obesity; one such method involves the use of anti-obese molecules. Compounds such as Orlistat, Lorcaserin, Sibutramine, Metformin and Hydroxycitric acid (HCA) are used as anti-obese molecules. Among these, Hydroxycitric acid is the preferred molecule since it shows high efficacy in controlling obesity, with minimal side effects. Several pharmaceutical companies extract HCA from the fruits of Garcinia cambogia, a native tree grown in south India. Due to geographical and seasonal limitation of Gracinia fruits, an alternative method of producing HCA is necessary.

Keywords


Garcinia cambogia, Hydroxy Citric Acid (HCA), Nuetraceutical, Antiobesity, Orlistat, Lorcaserin, Sibutramine, Metformin.

References