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A Review on In Situ Gel Forming Ophthalmic Drug Delivery Systems


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1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, India
     

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Nowadays ophthalmic route of administration of drugs is rapidly progressing and more studies are going on in formulating ophthalmic drug delivery systems. There are many conventional dosage forms available in the market like ointments, eye drops etc. The main drawback with these types of formulations is rapid drainage of the instilled dose due to the lacrimal fluid secretions and blinking of the eye lids. In order to minimize this drainage and to increase the ocular residence time and corneal contact time, in situ gel forming formulations are developed. In these systems sol to gel transformation takes place due to the environmental changes like pH, temperature, ionic strength. Some polymers like sodium alginate, HPMC are frequently used to initiate these processes. These formulations can be assessed for viscosity, clarity, gel strength, gelling capacity, gelling time, texture, isotonicity, sterility, ocular irritancy, anti-microbial efficacy, in vitro drug release, ex vivo release, in vivo absorption, in vivo retention and stability.

Keywords

In Situ Gel Formulations, Ophthalmic Drug Delivery Systems.
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  • Kumaran KS, Karthika K, Padmapreetha J. Comparative review on conventional and advanced ocular drug delivery formulations. Int. J. Pharm. Pharm. Sci. 2010; 2(4):1-5.
  • Kaur IP, Singh M, Kanwar M. Formulation and evaluation of ophthalmic preparations of acetazolamide. International journal of pharmaceutics. 2000 Apr 20; 199 (2):119-27.
  • Rathore KS, Nema RK. Formulation and evaluation of ophthalmic films for timolol maleate. Planta indica. 2008;4: 49-50.
  • Gurny R, Ibrahim H, Buri P. The development and use of in situ formed gels, triggered by pH. Biopharmaceutics of ocular drug delivery. 1993:81-90.
  • Mitan R, Gokulgandhi Jolly R, Parikh MB, Dharmesh MM. A pH triggered in situ gel forming ophthalmic drug delivery system for tropicamide. Drug Deliv Technol. 2007; 5:44-9.
  • Srividya B, Cardoza RM, Amin PD. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. Journal of controlled release. 2001 Jun 15;73(2):205-11.
  • Balasubramaniam J, Kant S, Pandit JK. In vitro and in vivo evaluation of Gelrite® gellan gum-based ocular delivery system for indomethacin. ACTA Pharmaceutica-Zagreb-. 2003 Dec; 53(4):251-62.
  • HB N, Bakliwal SR, Pawar SP. In situ gel: new trends in controlled and sustained drug delivery system.
  • Zarikar N, Kulkarni A, Patel R. Opthalmicin situ drug delivery system: a review. International Journal of Pharmaceutical Research and Development. 2013;5(05):48-55.
  • El-Laithy HM, Nesseem DI, Shoukry M. Evaluation of two in situ gelling systems for ocular delivery of Moxifloxacin: in vitro and in vivo studies. Journal of Chemical and Pharmaceutical Research. 2011; 3(2):66-79.
  • Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Advanced drug delivery reviews. 2005 Nov 3; 57(11):1595-639.
  • Sechoy O, Tissie G, Sebastian C, Maurin F, Driot JY, Trinquand C. A new long acting ophthalmic formulation of carteolol containing alginic acid. International journal of pharmaceutics. 2000 Oct 10; 207(1):109-16.
  • Lin HR, Sung KC. Carbopol/pluronic phase change solutions for ophthalmic drug delivery. Journal of Controlled Release. 2000 Dec 3; 69(3):379-88.
  • Kumar S, Himmelstein KJ. Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose. Journal of pharmaceutical sciences. 1995 Mar 1; 84(3):344-8.
  • Mali MN, Hajare AA. In situ gel-forming systems for sustained ocular drug delivery. European Industrial Pharmacy. 2010 Feb; 5:17-20.
  • Kumar L, Singh RP, Gupta S, Kumar D. In situ gel: a novel system for ocular drug delivery. International Journal of Pharmaceutical Sciences Review and Research. 2011; 9(2).
  • Parekh HB, Jivani R, Jivani NP, Patel LD, Makwana A, Sameja K. Novel insitu polymeric drug delivery system: a review. Journal of Drug Delivery and Therapeutics. 2012 Sep 15; 2(5).
  • HB N, Bakliwal SR, Pawar SP. In-situ gel: new trends in controlled and sustained drug delivery system.
  • Edsman K, Carlfors J, Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1;6(2):105-12.
  • Carlfors J, Edsman K, Petersson R, Jörnving K. Rheological evaluation of Gelrite® in situ gels for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1;6(2):113-9.
  • Kaur IP, Singh M, Kanwar M. Formulation and evaluation of ophthalmic preparations of acetazolamide. International journal of pharmaceutics. 2000 Apr 20; 199(2):119-27.
  • Kashyap N, Viswanad B, Sharma G, Bhardwaj V, Ramarao P, Kumar MR. Design and evaluation of biodegradable, biosensitive in situ gelling system for pulsatile delivery of insulin. Biomaterials. 2007 Apr 30; 28(11):2051-60.
  • Edsman K, Carlfors J, Harju K. Rheological evaluation and ocular contact time of some carbomer gels for ophthalmic use. International Journal of Pharmaceutics. 1996 Jun 28; 137(2):233-41.
  • Edsman K, Carlfors J, Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1; 6(2):105-12.
  • Lin CC, Metters AT. Hydrogels in controlled release formulations: network design and mathematical modeling. Advanced drug delivery reviews. 2006 Nov 30; 58(12):1379-408.
  • Rajoria G, Gupta A. In situ Gelling System: A novel approach for ocular drug delivery. AJPTR. 2012; 2:24-53.
  • Miyazaki S, Suisha F, Kawasaki N, Shirakawa M, Yamatoya K, Attwood D. Thermally reversible xyloglucan gels as vehicles for rectal drug delivery. Journal of Controlled Release. 1998 Dec 4; 56(1):75-83.
  • Bharathi D, Srinatha A, Ridhurkar DN, Singh S. Long acting ophthalmic formulation of indomethacin: Evaluation of alginate gel systems. Indian journal of pharmaceutical sciences. 2007; 69(1):37.
  • Sautou-Miranda V, Libert F, Grand-Boyer A, Gellis C, Chopineau J. Impact of deep freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions. International journal of pharmaceutics. 2002 Mar 2; 234(1):205-12.
  • Kashyap N, Viswanad B, Sharma G, Bhardwaj V, Ramarao P, Kumar MR. Design and evaluation of biodegradable, biosensitivein situ gelling system for pulsatile delivery of insulin. Biomaterials. 2007 Apr 30; 28(11):2051-60.
  • Mohanambal E, Arun K, Sathali AH. Formulation and evaluation of pH-triggered in situ gelling system of levofloxacin. Indian Journal of Pharmaceutical Education and Research. 2011 Jan 1; 45(1):58-64.
  • Jones DS, Woolfson AD, Brown AF. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. International journal of pharmaceutics. 1997 May 26; 151(2):223-33.
  • Rathore KS, Nema RK. An insight into ophthalmic drug delivery system. Int J Pharm Sci Drug Res. 2009 Apr;1(1):1-5.
  • Rathore KS, Nema RK. Management of Glaucoma: a review. Int. J. Pharmtech Res. 2009; 1(3):863-9.
  • Doshi HA, Bhalla HL. Preparation and Evaluation of New Eye-Drops Containing A Combination of Ciprofloxacin and Dexamethasone. Indian Drugs-Bombay-. 2000;37(4):190-5.
  • Vodithala S, Khatry S, Shastri N, Sadanandam M. Development and evaluation of thermoreversible ocular gels of ketorolac tromethamine. Int J Biopharm. 2010; 1(1):39-45.
  • Mundada AS, Shrikhande BK. Formulation and evaluation of ciprofloxacin hydrochloride soluble ocular drug insert. Current eye research. 2008 Jan 1; 33(5-6):469-75.
  • Mitan R, Gokulgandhi Jolly R, Parikh MB, Dharmesh MM. A pH triggered in situ gel forming ophthalmic drug delivery system for tropicamide. Drug Deliv Technol. 2007; 5:44-9.
  • Rittenhouse KD, Pollack GM. Microdialysis and drug delivery to the eye. Advanced drug delivery reviews. 2000 Dec 15; 45(2):229-41.
  • Gupta S, Vyas SP. Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate. Scientia pharmaceutica. 2010 Oct 5; 78(4):959-76.
  • Urtti A, Pipkin JD, Rork G, Repta AJ. Controlled drug delivery devices for experimental ocular studies with timolol 1. In vitro release studies. International Journal of Pharmaceutics. 1990 Jun 30; 61(3):235-40.
  • Doijad RC, Manvi FV, Rao VM, Alase P. Sustained ophthalmic delivery of gatifloxacin from in situ gelling system. Indian journal of pharmaceutical sciences. 2006; 68(6):814.
  • Rupenthal ID, Green CR, Alany RG. Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: physicochemical characterization and in vitro release. International journal of pharmaceutics. 2011 Jun 15; 411(1):69-77.
  • Sawarkar S, Ravikumar P, Pashte S. In situ ophthalmic gel forming solution of moxifloxacin hydrochloride for sustained ocular delivery. International Journal of Pharmaceutical Sciences and Research. 2016 Mar 1; 7(3):1192.
  • Wagh VD, Deshmukh KH, Wagh KV. Formulation and evaluation of in situ gel drug delivery system of Sesbania grandiflora flower extract for the treatment of bacterial conjunctivitis. J Pharm Res. 2012; 4: 1880-4.
  • Nagesh C, Patil M, Chandrashekhara S, Sutar R. A novel in situ gel for sustained ophthalmic delivery of Ciprofloxacin hydrochloride and Dexamethasone-design and characterization. Der Pharmacia Lettre. 2012; 4(3):821-7.
  • Patil S, Kadam A, Bandgar S, Patil S. Formulation and Evaluation of an in situ gel for Ocular Drug Delivery of Anticonjunctival Drug. Cellulose Chemistry and Technology. 2015 Jan 1; 49(1):35-40.
  • Aparna VB, Sitanshu SS. In situ gelling ophthalmic drug delivery system for glaucoma. International Journal of Pharma and Bio Sciences, 2011;2(2):7-14
  • Mohan EC, KanduKuri JM, Allenki V. Preparation and evaluation of in-situ-gels for ocular drug delivery. Journal of Pharmacy Research 2009, 2 (6), 1089. 2009 Jun;1094
  • Puranik KM, Tagalpallewar AA. Voriconazole In situ Gel for Ocular Drug Delivery. SOJ Pharm Pharm Sci, 2 (2), 1-10.
  • Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. Journal of controlled release. 1997 Feb 17; 44(2):201-8.Abstract.
  • Sterile ophthalmic gel forming solution, Timoptic-XE®, 0.25% and 0.5%, (Timolol maleate ophthalmic gel forming solution), Merck and Company Inc. NJ 08889: Whitehouse Station, USA.

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  • A Review on In Situ Gel Forming Ophthalmic Drug Delivery Systems

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Authors

Harsha Vardhani Kondepati
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, India
Girish Pai Kulyadi
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, India
Vamshi Krishna Tippavajhala
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka State, India

Abstract


Nowadays ophthalmic route of administration of drugs is rapidly progressing and more studies are going on in formulating ophthalmic drug delivery systems. There are many conventional dosage forms available in the market like ointments, eye drops etc. The main drawback with these types of formulations is rapid drainage of the instilled dose due to the lacrimal fluid secretions and blinking of the eye lids. In order to minimize this drainage and to increase the ocular residence time and corneal contact time, in situ gel forming formulations are developed. In these systems sol to gel transformation takes place due to the environmental changes like pH, temperature, ionic strength. Some polymers like sodium alginate, HPMC are frequently used to initiate these processes. These formulations can be assessed for viscosity, clarity, gel strength, gelling capacity, gelling time, texture, isotonicity, sterility, ocular irritancy, anti-microbial efficacy, in vitro drug release, ex vivo release, in vivo absorption, in vivo retention and stability.

Keywords


In Situ Gel Formulations, Ophthalmic Drug Delivery Systems.

References