Research Journal of Pharmacy and Technology

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Formulation of Modified Release Pellets of Montelukast Sodium


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1 Dr. D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra- 411018., India
     

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The present study was carried out with an aim of preparing modified release pellets of the antiasthma drug montelukast sodium. The patients suffering from chronic asthma many a times suffer from exacerbations during the early morning hours i.e. around 4am to 6 am. Thus the need to take an immediate release medication arises during early morning hours which is not quiet feasible for the patients. The delivery of the drug at this time can be made possible by the use of modified release formulation of montelukast sodium which when taken at the bed time would release the drug as a pulsed delivery without the need of the patient to wake up. The montelukast sodium pellets prepared by extrusion-spheronization were coated with release retarding polymer ethyl cellulose using the Wurster method. The ethyl cellulose coating helped in lag time increase due to prolonged water uptake time. The increase in the coating level increased the lag time sufficiently that might release the drug during the early morning hours. Thus a modified release pellets dosage form to prevent the early morning asthma attacks and exacerbations was developed successfully.

Keywords

Chronotherapy, Extrusion- Spheronization, Coating Level, Lag Time, Anti-Asthma.
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  • Muley S., Nandgude T, Poddar S. , Extrusion–spheronization a promising pelletization technique: In-depth review Asian journal of pharmaceutical sciences,2016; 684-699.

  • Chambliss W.G., Sellassie I., Pharmaceutical Pelletization Technology Marcel Dekker, New York 1998; 15.

  • Sandberg A., Ragnarsson G., Jonsson U., Sjogren J., Design of a new multiple-unit controlled-release formulation of metoprolol--metoprolol CR, Eur. J. Clin. Pharmacol., S3, 1998; 33.

  • Mehta K.A. et. al, Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix, International Journal Pharmacy, 2, 7,2001, 213.

  • Patel H. et. al., Dissolution rate improvement of telmisartan through modified MCC pellets using 32 full factorial design, Saudi Pharmaceutical Journal 2015;1-9.

  • Paul Wan SiaHeng.: Pelletization and Pellets coating 15th international symposium on microencapsulation. Parma Italy; Sep 2005; 18-21.

  • Rowe R., et.al., Size and distribution on capsule filling- A preliminary evaluation of three-dimensional computer simulation using a Monte –Carlo technique, Int. J. Pharm. 300, 2005; 32-37.

  • Raymond C.et al., Hand book of pharmaceutical Excipient; Ed.4th, 487-488.

  • Jha N., Bapat S., Chronobiology and chronotherapeutics, Kathmandu Uni. Med. J., 2004; 2 (8), 384-388.

  • Arora S. et.al., Pulsatile drug delivery systems: An approach for controlled drug delivery, Ind. J. Pharm. Sci., 2006; 68, 295-300.

  • Gothaskar A.V., Joshi A.M., Joshi N. H., Pulsatile Drug Delivery Systems: A Review, Drug Del. Tech., 2004; 4-5.

  • Smolensky M. , Lemmer B., Reinberg A., Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma, Advanced Drug Delivery Reviews 59, 2007; 852–882.

  • Poddar S.S., et.al., Fabrication of Pulsatile delivery multiparticulate system of poorly water soluble carvedilol phosphate, International research journal of pharmacy, 2012, 3(9), 235-240.

  • Nandgude T., Bhise K.,Gupta V., Characterization of hydrochloride and tannate salts of diphenhydramine, Indian journal of pharmaceutical sciences 70, 4 , 2008; 482.

  • Muley S. et al., Formulation and Optimization of Lansoprazole Pellets Using Factorial Design Prepared by Extrusion-Spheronization Technique Using Carboxymethyl Tamarind Kernel Powder, Recent Pat Drug Deliv Formulation, 2017 Jan 13. [Epub ahead of print].

  • Rahman A., et. al., Recent advance in pelletization technique for oral drug delivery: A review, Current Drug Delivery,2009; 6, 122-129.

  • Hire N., Microparticulate drug delivery system for topical administration of itraconazole, Asian Journal of Pharmaceutics, 83-88.

  • Chivate A., Evaluation of Sterculia foetida Gum as Controlled Release Excipient, AAPS Pharm Sci Tech, Vol. 9, No. 1, 2008,197-204.


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  • Formulation of Modified Release Pellets of Montelukast Sodium

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Authors

Susmit S. Diggikar
Dr. D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra- 411018., India
Tanaji D. Nandgude
Dr. D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra- 411018., India
Sushilkumar S. Poddar
Dr. D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra- 411018., India

Abstract


The present study was carried out with an aim of preparing modified release pellets of the antiasthma drug montelukast sodium. The patients suffering from chronic asthma many a times suffer from exacerbations during the early morning hours i.e. around 4am to 6 am. Thus the need to take an immediate release medication arises during early morning hours which is not quiet feasible for the patients. The delivery of the drug at this time can be made possible by the use of modified release formulation of montelukast sodium which when taken at the bed time would release the drug as a pulsed delivery without the need of the patient to wake up. The montelukast sodium pellets prepared by extrusion-spheronization were coated with release retarding polymer ethyl cellulose using the Wurster method. The ethyl cellulose coating helped in lag time increase due to prolonged water uptake time. The increase in the coating level increased the lag time sufficiently that might release the drug during the early morning hours. Thus a modified release pellets dosage form to prevent the early morning asthma attacks and exacerbations was developed successfully.

Keywords


Chronotherapy, Extrusion- Spheronization, Coating Level, Lag Time, Anti-Asthma.

References