Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Relationship Between Ghrelin and Leptin with Insulin Resistance in Obese Patients and Non-Obese Individuals


Affiliations
1 Iraqi Ministry of Health, Babylon University, Iraq
2 Babylon University, Iraq
     

   Subscribe/Renew Journal


Experimental studies have suggested that Ghrelin and Leptin play a role in glucose homeostasis, and thus any disturbance to their action might lead to Insulin resistance, Obesity and type II Diabetes Mellitus, thus we assess the hypothesis that low Ghrelin concentration and high Leptin concentration are a risk factor for obesity and Insulin resistance. The materials and methods: One hundred people were included in this study: fifty obese patients and fifty non-obese. The mean age for the study group was (34.00±9.43) years old while that of the control group was (34.00±9.43) year's old respectively, they were classified according to their Body Mass Index after measuring their height and weight, the mean BMI of case patients was (39.23±6.71kg/m²) and (23.08±1.19 kg/m²) for the control individuals, exclusion Criteria included: history of diabetes mellitus; finding of high blood glucose on biochemical examination, history of taking drugs that cause obesity or increase in body weight such as steroids, patients with diseases of high growth hormone level such as acromegaly, pregnant women, while the investigations that were done including: Fasting blood sugar, fasting serum Ghrelin, fasting serum Leptin and fasting serum Insulin, Insulin resistance was measured using HOMA-IR module. Results showed that there is association between insulin resistance and obesity as it well known and a significant relation between fasting serum Leptin with Obesity/Insulin resistance (p value>0.05) but a non-significant relation between fasting serum Ghrelin and Obesity/Insulin Resistance (p value>0.05). Conclusion: Obesity is associated with insulin resistance with high level of fasting serum Leptin but with not high level of fasting serum Ghrelin.

Keywords

Obesity, Insulin resistance, Ghrelin, Leptin.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Yanovski, S.Z. and Yanovski, J.A. (2014). Long-term drug treatment for obesity: a systemic and clinical review. JAMA: the Journal of American Medical Association 311 (1): 74-68.

  • Colledge, N.R.; Walker, B. R. and Ralston, S.H. (2010). Davidson’s: Principles and practice of medicine. 18th edit., Churchil Livingston; Pp: 797-828.

  • Kushner, R. (2007). Treatment of the Obese Patient (Contemporary Endocrinology). Totowa, NJ: Humana Press. p. 158.

  • Haslam, D.W. and James, W.P. (2005). Obesity. Lancet 366(9492): 1197-209.

  • Sakata I, Sakai T (2010). "Ghrelin cells in the gastrointestinal tract". International Journal of Peptides 2010: 1–7.

  • Burger KS, Berner LA (September 2014). "A functional neuroimaging review of obesity, appetitive hormones and digestive behavior". Physiology and Behavior 136: 121–7.

  • Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D (August 2004). "Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues". American Journal of Physiology. Endocrinology and Metabolism 287 (2): E297–304.

  • Considine RV, Nyce MR, Kolaczynski JW, Zhang PL, Ohannesian JP, Moore JH, Fox JW, Caro JF (May 1997). "Dexamethasone stimulates leptin release from human adipocytes: unexpected inhibition by insulin". J. Cell. Biochem. 65 (2): 254–8.

  • Brennan AM, Mantzoros CS (2006). "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications". Nat Clin Pract Endocrinol Metab 2 (6): 318–27.

  • Pan H, Guo J, Su Z (May 2014). "Advances in understanding the interrelations between leptin resistance and obesity". Physiology and Behavior 130: 157–169.

  • Bastard J. P., Mustapha Maachi, Claire Lagathu, Min Ji Kim, Martine Caron, Hubert Vidal, Jacqueline Capeau, Bruno Feve; 2006.European Cytokine Network. 2006 Mar; 17 (1):4-12. Recent advances in the relationship between obesity, inflammation, and insulin resistance.

  • Fahim Abbasi, MD*; Byron William Brown, PhD†; Cindy Lamendola, MSN, ANP*; Tracey McLaughlin, MD*; Gerald M Reaven, MD; 2002*Journal of the American College of Cardiology Volume 40, Issue 5, September 2002 DOI: 10.1016/S0735-1097(02)02051-X, Relationship between obesity, insulin resistance, and coronary heart disease risk.

  • McLaughlin T., Fahim Abbasi, Cindy Lamendola, R. Scott Frayo, and David E. Cummings; 2009.The Journal of Clinical Endocrinology and Metabolism: Vol 89, No 4

  • Seppo M. Pöykkö, Eija Kellokoski, Sohvi Hörkkö, Heikki Kauma, Y. Antero Kesäniemi and Olavi Ukkola; 2003. Diabetes 2003 Oct; 52(10): 2546-2553, Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes.

  • Waleed S. Mohamed1,2*, Mohammed A. Hassanien2,3 and Khalid EL Sayed Abokhosheim3 2014.Endocrinology and Metabolic Syndrome, Role of Ghrelin, Leptin and Insulin Resistance in Development of Metabolic Syndrome in Obese Patients.

  • Purnell JQ1, Weigle DS, Breen P, Cummings DE 2003.J Clinical Endocrinology and Metabolism. 2003 Dec; 88(12):5747-52. Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans.

  • Miriam Cnop1, Melinda J. Landchild1, Josep Vidal1, Peter J. Havel3, Negar G. Knowles1, Darcy R. Carr2, Feng Wang1, Rebecca L. Hull1, Edward J. Boyko1, Barbara M. Retzlaff1, Carolyn E. Walden4, Robert H. Knopp1 and Steven E. Kahn1 2002Diabetes 2002 Apr; 51(4): 1005-1015. The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations.


Abstract Views: 192

PDF Views: 0




  • Relationship Between Ghrelin and Leptin with Insulin Resistance in Obese Patients and Non-Obese Individuals

Abstract Views: 192  |  PDF Views: 0

Authors

Doaa Mahdi Omran
Iraqi Ministry of Health, Babylon University, Iraq
Saad Merza Alaraji
Babylon University, Iraq
Ali Hussein Albayati
Babylon University, Iraq
Wathiq Essam
Iraqi Ministry of Health, Babylon University, Iraq

Abstract


Experimental studies have suggested that Ghrelin and Leptin play a role in glucose homeostasis, and thus any disturbance to their action might lead to Insulin resistance, Obesity and type II Diabetes Mellitus, thus we assess the hypothesis that low Ghrelin concentration and high Leptin concentration are a risk factor for obesity and Insulin resistance. The materials and methods: One hundred people were included in this study: fifty obese patients and fifty non-obese. The mean age for the study group was (34.00±9.43) years old while that of the control group was (34.00±9.43) year's old respectively, they were classified according to their Body Mass Index after measuring their height and weight, the mean BMI of case patients was (39.23±6.71kg/m²) and (23.08±1.19 kg/m²) for the control individuals, exclusion Criteria included: history of diabetes mellitus; finding of high blood glucose on biochemical examination, history of taking drugs that cause obesity or increase in body weight such as steroids, patients with diseases of high growth hormone level such as acromegaly, pregnant women, while the investigations that were done including: Fasting blood sugar, fasting serum Ghrelin, fasting serum Leptin and fasting serum Insulin, Insulin resistance was measured using HOMA-IR module. Results showed that there is association between insulin resistance and obesity as it well known and a significant relation between fasting serum Leptin with Obesity/Insulin resistance (p value>0.05) but a non-significant relation between fasting serum Ghrelin and Obesity/Insulin Resistance (p value>0.05). Conclusion: Obesity is associated with insulin resistance with high level of fasting serum Leptin but with not high level of fasting serum Ghrelin.

Keywords


Obesity, Insulin resistance, Ghrelin, Leptin.

References