Research Journal of Pharmacy and Technology

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Application of Dipterocarpus alatus Oil for Permeation Enhancement of Some Compounds


Affiliations
1 Division of Pharmaceutical Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand
2 Khon Kaen University, Khon Kaen, 40002, Thailand
3 Division of Pharmaceutical Technology, Khon Kaen University, Khon Kaen, 40002, Thailand
     

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The absorption of some drugs through skin is minimized due to the barrier of stratum corneum layerTherefore, searching for the new penetration enhancer from some chemical and natural compounds was widely investigatedNatural oil from Dipterocarpus alatus is very high production and supply in many parts of Thailand and is one of the potential natural oil which might be use for drug formulationThus, the aim of this study was to investigate the penetration enhancement of this natural oil to improve the permeation ability of some drugsKetoconazole, caffeine and ibuprofen were the model of drug use in this studySide by side diffusion testing was used for the study of the permeation enhancement of D.alatus oil and the amount of drug permeate was determined by UV-Visible spectrophotometerThe results were shown that D.alatus oil might be used as a permeation enhancer of some model drugs and could be applied to use as the excipient in drug formulation.

Keywords

Dipterocarpus alatus, Permeation Enhancement, Caffeine, Ketoconazole, Ibuprofen.
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  • Application of Dipterocarpus alatus Oil for Permeation Enhancement of Some Compounds

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Authors

Supawadee Daodee
Division of Pharmaceutical Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand
Tanakorn Punya
Khon Kaen University, Khon Kaen, 40002, Thailand
Narin Chansri
Division of Pharmaceutical Technology, Khon Kaen University, Khon Kaen, 40002, Thailand

Abstract


The absorption of some drugs through skin is minimized due to the barrier of stratum corneum layerTherefore, searching for the new penetration enhancer from some chemical and natural compounds was widely investigatedNatural oil from Dipterocarpus alatus is very high production and supply in many parts of Thailand and is one of the potential natural oil which might be use for drug formulationThus, the aim of this study was to investigate the penetration enhancement of this natural oil to improve the permeation ability of some drugsKetoconazole, caffeine and ibuprofen were the model of drug use in this studySide by side diffusion testing was used for the study of the permeation enhancement of D.alatus oil and the amount of drug permeate was determined by UV-Visible spectrophotometerThe results were shown that D.alatus oil might be used as a permeation enhancer of some model drugs and could be applied to use as the excipient in drug formulation.

Keywords


Dipterocarpus alatus, Permeation Enhancement, Caffeine, Ketoconazole, Ibuprofen.

References